Cholecystokinin

CCK

Identifiers

External IDs

Gene ontology
Molecular function	• hormone activity • protein binding • neuropeptide hormone activity
Cellular component	• perikaryon • extracellular region • terminal bouton • neuronal cell body • dendrite • axon hillock • axon initial segment • extracellular space • axon
Biological process	• regulation of sensory perception of pain • eating behavior • behavioral fear response • negative regulation of appetite • protein kinase C-activating G-protein coupled receptor signaling pathway • positive regulation of mitochondrial depolarization • positive regulation of glutamate secretion • positive regulation of cell proliferation • positive regulation of protein oligomerization • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • signal transduction • release of cytochrome c from mitochondria • apoptotic process • neuron migration • axonogenesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


885


12424


ENSG00000187094


ENSMUSG00000032532


P06307


P09240

RefSeq (mRNA)


NM_000729 NM_001174138


NM_031161 NM_001284508

RefSeq (protein)


NP_000720 NP_001167609


NP_001271437.1 NP_112438.1 NP_001271437 NP_112438

Location (UCSC)

PubMed search

Cholecystokinin (CCK or CCK-PZ; from Greek chole, "bile"; cysto, "sac"; kinin, "move"; hence, move the bile-sac (gallbladder)) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. Cholecystokinin, previously called pancreozymin, is synthesized and secreted by enteroendocrine cells in the duodenum, the first segment of the small intestine. Its presence causes the release of digestive enzymes and bile from the pancreas and gallbladder, respectively, and also acts as a hunger suppressant.