Src gene

CSK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BYG, 1CSK, 3D7T, 3D7U, 3EAC, 3EAZ
Identifiers
Aliases	CSK, Src, c-src tyrosine kinase, CSK/Src, non-receptor tyrosine kinase, C-terminal Src kinase
External IDs	MGI: 88537 HomoloGene: 55818 GeneCards: CSK
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein kinase A catalytic subunit binding • non-membrane spanning protein tyrosine kinase activity • metal ion binding • protein C-terminus binding • protein binding • identical protein binding • protein tyrosine kinase activity • protein phosphatase binding • proline-rich region binding • receptor binding • ATP binding • kinase activity Cellular component • cytoplasm • cytosol • membrane • cell-cell junction • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • membrane raft • extracellular exosome Biological process • cell differentiation • adaptive immune response • positive regulation of MAP kinase activity • epidermal growth factor receptor signaling pathway • negative regulation of phagocytosis • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • negative regulation of low-density lipoprotein particle clearance • immune system process • negative regulation of interleukin-6 production • T cell costimulation • oligodendrocyte differentiation • negative regulation of Golgi to plasma membrane protein transport • regulation of Fc receptor mediated stimulatory signaling pathway • regulation of cytokine production • protein phosphorylation • brain development • cellular response to peptide hormone stimulus • regulation of cell proliferation • peptidyl-tyrosine autophosphorylation • negative regulation of ERK1 and ERK2 cascade • protein autophosphorylation • innate immune response • adherens junction organization • T cell receptor signaling pathway • negative regulation of cell proliferation • negative regulation of bone resorption • negative regulation of kinase activity • central nervous system development • peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1445	12988
Ensembl	ENSG00000103653	ENSMUSG00000032312
UniProt	P41240	P41241
RefSeq (mRNA)	NM_001127190 NM_004383	NM_007783 NM_001304761
RefSeq (protein)	NP_001120662 NP_004374	NP_001291690 NP_031809
Location (UCSC)	Chr 15: 74.78 – 74.8 Mb	Chr 9: 57.63 – 57.65 Mb
PubMed search

1BYG, 1CSK, 3D7T, 3D7U, 3EAC, 3EAZ

1445

12988

ENSG00000103653

ENSMUSG00000032312

P41240

P41241

NM_001127190
NM_004383

NM_007783
NM_001304761

NP_001120662
NP_004374

NP_001291690
NP_031809

Tyrosine-protein kinase CSK also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. This enzyme phosphorylates tyrosine residues located in the C-terminal end of Src-family kinases (SFKs) including SRC, HCK, FYN, LCK, LYN and YES1.

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