LYN

LYN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W1F, 1WA7, 3A4O
Identifiers
Aliases	LYN, LYN proto-oncogene, Src family tyrosine kinase, JTK8, p53Lyn, p56Lyn
External IDs	OMIM: 165120 MGI: 96892 HomoloGene: 55649 GeneCards: LYN
Gene ontology Molecular function • ion channel binding • SH3 domain binding • protein complex binding • kinase activity • gamma-tubulin binding • receptor binding • ATP binding • protein kinase activity • signal transducer, downstream of receptor, with protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • enzyme binding • transferase activity • platelet-derived growth factor receptor binding • integrin binding • protein binding • glycosphingolipid binding • protein tyrosine kinase activity • nucleotide binding • phosphoprotein binding • ubiquitin protein ligase binding Cellular component • cytoplasm • cytosol • membrane • extrinsic component of cytoplasmic side of plasma membrane • mitochondrial intermembrane space • perinuclear region of cytoplasm • nucleus • mitochondrial membrane • membrane raft • extracellular exosome • Golgi apparatus • plasma membrane • postsynaptic density • mast cell granule • cell-cell adherens junction • integrin alpha2-beta1 complex • mitochondrial crista • intracellular membrane-bounded organelle Biological process • regulation of protein phosphorylation • cellular response to extracellular stimulus • cellular response to retinoic acid • positive regulation of B cell receptor signaling pathway • tolerance induction to self antigen • regulation of mast cell activation • regulation of cell adhesion mediated by integrin • cellular response to heat • response to amino acid • hemopoiesis • adaptive immune response • regulation of erythrocyte differentiation • cellular response to DNA damage stimulus • positive regulation of Fc receptor mediated stimulatory signaling pathway • platelet activation • Fc-epsilon receptor signaling pathway • protein phosphorylation • regulation of B cell apoptotic process • positive regulation of dendritic cell apoptotic process • positive regulation of glial cell proliferation • response to carbohydrate • regulation of platelet aggregation • negative regulation of cell proliferation • B cell receptor signaling pathway • negative regulation of myeloid leukocyte differentiation • dendritic cell differentiation • Fc receptor mediated inhibitory signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • transmembrane receptor protein tyrosine kinase signaling pathway • regulation of B cell receptor signaling pathway • regulation of cytokine secretion • stimulatory C-type lectin receptor signaling pathway • response to sterol depletion • positive regulation of stress-activated protein kinase signaling cascade • regulation of cytokine production • response to insulin • positive regulation of mast cell proliferation • negative regulation of MAP kinase activity • regulation of ERK1 and ERK2 cascade • positive regulation of peptidyl-tyrosine phosphorylation • erythrocyte differentiation • protein autophosphorylation • oligodendrocyte development • regulation of mast cell degranulation • positive regulation of phosphorylation • viral process • response to toxic substance • negative regulation of protein phosphorylation • Fc receptor mediated stimulatory signaling pathway • JAK-STAT cascade involved in growth hormone signaling pathway • phosphorylation • immune system process • regulation of release of sequestered calcium ion into cytosol • positive regulation of tyrosine phosphorylation of STAT protein • B cell homeostasis • immune response-regulating cell surface receptor signaling pathway • response to axon injury • negative regulation of mast cell proliferation • regulation of inflammatory response • peptidyl-tyrosine autophosphorylation • response to hormone • positive regulation of cellular component movement • regulation of monocyte chemotaxis • leukocyte migration • lipopolysaccharide-mediated signaling pathway • histamine secretion by mast cell • intracellular signal transduction • response to organic cyclic compound • negative regulation of intracellular signal transduction • positive regulation of cell migration • ephrin receptor signaling pathway • negative regulation of toll-like receptor 2 signaling pathway • cytokine secretion • T cell costimulation • response to peptide hormone • platelet degranulation • blood coagulation • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of oligodendrocyte progenitor proliferation • negative regulation of immune response • positive regulation of cell proliferation • positive regulation of neuron projection development • negative regulation of ERK1 and ERK2 cascade • peptidyl-tyrosine phosphorylation • negative regulation of B cell proliferation • response to drug • negative regulation of toll-like receptor 4 signaling pathway • signal transduction • innate immune response • neuron projection development • signal transduction by protein phosphorylation • central nervous system development • inflammatory response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4067	17096
Ensembl	ENSG00000254087	ENSMUSG00000042228
UniProt	P07948	P25911
RefSeq (mRNA)	NM_001111097 NM_002350	NM_001111096 NM_010747
RefSeq (protein)	NP_001104567 NP_002341	NP_001104566.1 NP_001104566 NP_034877
Location (UCSC)	Chr 8: 55.88 – 56.01 Mb	Chr 4: 3.68 – 3.81 Mb
PubMed search

1W1F, 1WA7, 3A4O

4067

17096

ENSG00000254087

ENSMUSG00000042228

P07948

P25911

NM_001111097
NM_002350

NM_001111096
NM_010747

NP_001104567
NP_002341

NP_001104566.1
NP_001104566
NP_034877

Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene.

Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. In various hematopoietic cells, Lyn has emerged as a key enzyme involved in the regulation of cell activation. In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor (BCR),CD40, or CD19. The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase, Lck and Yes also being members of the Src kinase family.

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