CD19

Identifiers

CD19, B4, CVID3, CD19 molecule

External IDs

OMIM: 107265 MGI: 88319 HomoloGene: 1341 GeneCards: CD19

Gene ontology
Molecular function	• signal transducer activity, downstream of receptor • protein binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Cellular component	• integral component of membrane • plasma membrane • integral component of plasma membrane • extracellular exosome • membrane • protein complex • external side of plasma membrane • intracellular
Biological process	• cellular defense response • cell surface receptor signaling pathway • phosphatidylinositol-mediated signaling • regulation of immune response • positive regulation of release of sequestered calcium ion into cytosol • phosphatidylinositol phosphorylation • B cell receptor signaling pathway • regulation of phosphatidylinositol 3-kinase signaling
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


930


12478

Ensembl


ENSG00000177455


ENSMUSG00000030724

UniProt


P15391


P25918

RefSeq (mRNA)


NM_001178098 NM_001770


NM_009844

RefSeq (protein)


NP_001171569 NP_001761


NP_033974.2 NP_033974

Location (UCSC)

Chr 16: 28.93 – 28.94 Mb

Chr 7: 126.41 – 126.41 Mb

PubMed search

NM_001178098
NM_001770

NM_009844

NP_001171569
NP_001761

NP_033974.2
NP_033974

B-lymphocyte antigen CD19, also known as CD19 (Cluster of Differentiation 19), is a protein that in humans is encoded by the CD19 gene. It is found on the surface of B-cells, a type of white blood cell.

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. The CD19 gene encodes a cell surface molecule that assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

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Wikipedia