CD40

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1CZZ, 1D00, 1FLL, 1LB6, 3QD6, 5DMJ, 5IHL, 5DMI

Identifiers

Aliases

CD40, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule

External IDs

MGI: 88336 HomoloGene: 954 GeneCards: CD40

Genetically Related Diseases

rheumatoid arthritis

Gene ontology
Molecular function	• antigen binding • signal transducer activity • protein binding • tumor necrosis factor-activated receptor activity • enzyme binding • ubiquitin protein ligase binding • receptor activity • protein domain specific binding
Cellular component	• cytoplasm • integral component of membrane • intracellular membrane-bounded organelle • membrane • plasma membrane • integral component of plasma membrane • extracellular region • cell surface • CD40 receptor complex • extracellular exosome • external side of plasma membrane • extracellular space • neuronal cell body • varicosity
Biological process	• positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • positive regulation of interleukin-12 production • protein kinase B signaling • protein complex assembly • regulation of immunoglobulin secretion • positive regulation of protein kinase C signaling • immune system process • cellular calcium ion homeostasis • tumor necrosis factor-mediated signaling pathway • immune response-regulating cell surface receptor signaling pathway • platelet activation • multicellular organism development • B cell activation • positive regulation of GTPase activity • response to lipopolysaccharide • B cell proliferation • cellular response to mechanical stimulus • positive regulation of endothelial cell apoptotic process • regulation of cell proliferation • positive regulation of B cell proliferation • positive regulation of NF-kappaB transcription factor activity • defense response to virus • immune response • regulation of immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • apoptotic signaling pathway • positive regulation of isotype switching to IgG isotypes • cellular response to lipopolysaccharide • positive regulation of tyrosine phosphorylation of Stat1 protein • positive regulation of transcription from RNA polymerase II promoter • defense response to protozoan • response to bacterium • response to nutrient levels • response to cobalamin • response to interferon-gamma • cellular response to erythropoietin • cellular response to interleukin-1 • cellular response to tumor necrosis factor • response to peptide • inflammatory response
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


958


21939

Ensembl


ENSG00000101017


ENSMUSG00000017652

UniProt


P25942


P27512

RefSeq (mRNA)


NM_001250 NM_001302753 NM_152854 NM_001322421 NM_001322422


NM_011611 NM_170702 NM_170703 NM_170704

RefSeq (protein)


NP_001241 NP_001289682 NP_001309350 NP_001309351 NP_690593

NP_035741.2 NP_733803.2 NP_733804.1 NP_733805.1 NP_035741
NP_733803 NP_733804 NP_733805

Location (UCSC)

Chr 20: 46.12 – 46.13 Mb

Chr 2: 165.06 – 165.07 Mb

PubMed search

1CZZ, 1D00, 1FLL, 1LB6, 3QD6, 5DMJ, 5IHL, 5DMI

NM_001250
NM_001302753
NM_152854
NM_001322421
NM_001322422

NM_011611
NM_170702
NM_170703
NM_170704

...
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