YES1

YES1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HDA
Identifiers
Aliases	YES1, HsT441, P61-YES, Yes, c-yes, YES proto-oncogene 1, Src family tyrosine kinase
External IDs	MGI: 99147 HomoloGene: 55900 GeneCards: YES1
Targeted by Drug
saracatinib, SU6656
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • ion channel binding • epidermal growth factor receptor binding • non-membrane spanning protein tyrosine kinase activity • kinase activity • protein binding • enzyme binding • protein tyrosine kinase activity • receptor binding • ATP binding Cellular component • Golgi apparatus • membrane • focal adhesion • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • microtubule organizing center • actin filament • extracellular exosome • cytoskeleton • cytoplasm • cytosol Biological process • cellular response to transforming growth factor beta stimulus • cellular response to retinoic acid • cell differentiation • Fc-gamma receptor signaling pathway involved in phagocytosis • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • ephrin receptor signaling pathway • T cell costimulation • cellular response to platelet-derived growth factor stimulus • protein phosphorylation • regulation of vascular permeability • cellular protein modification process • regulation of cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • leukocyte migration • glucose transport • positive regulation of transcription from RNA polymerase II promoter • innate immune response • cell migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7525	22612
Ensembl	ENSG00000176105	ENSMUSG00000014932
UniProt	P07947	Q04736
RefSeq (mRNA)	NM_005433	NM_001205132 NM_001205133 NM_009535
RefSeq (protein)	NP_005424	NP_001192061.1 NP_001192062.1 NP_033561.1 NP_001192061 NP_001192062 NP_033561
Location (UCSC)	Chr 18: 0.72 – 0.81 Mb	Chr 5: 32.61 – 32.69 Mb
PubMed search

2HDA

7525

22612

ENSG00000176105

ENSMUSG00000014932

P07947

Q04736

NM_005433

NM_001205132
NM_001205133
NM_009535

NP_005424

NP_033561

Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene.

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.

YES1 has been shown to interact with Janus kinase 2,CTNND1,RPL10 and Occludin.

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Wikipedia