Occludin

OCLN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WPA, 1XAW, 3G7C
Identifiers
Aliases	OCLN, BLCPMG, PPP1R115, occludin
External IDs	OMIM: 602876 MGI: 106183 HomoloGene: 1905 GeneCards: OCLN
Gene ontology Molecular function • protein domain specific binding • protein binding Cellular component • integral component of membrane • membrane • cell-cell junction • bicellular tight junction • plasma membrane • endocytic vesicle • cell junction • apicolateral plasma membrane • apical plasma membrane • cytoplasmic vesicle • lateral plasma membrane Biological process • cell-cell junction organization • protein complex assembly • bicellular tight junction assembly • response to interleukin-18 • cellular response to tumor necrosis factor Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	100506658	18260
Ensembl	n/a	ENSMUSG00000021638
UniProt	Q16625	Q61146
RefSeq (mRNA)	NM_002538 NM_001205254 NM_001205255	NM_008756
RefSeq (protein)	NP_001192183 NP_001192184 NP_002529	NP_032782.1 NP_032782
Location (UCSC)	Chr 5: 69.49 – 69.56 Mb	Chr 13: 100.5 – 100.55 Mb
PubMed search

1WPA, 1XAW, 3G7C

100506658

18260

n/a

ENSMUSG00000021638

Q16625

Q61146

NM_002538
NM_001205254
NM_001205255

NM_008756

NP_001192183
NP_001192184
NP_002529

NP_032782.1
NP_032782

Occludin is a protein that in humans is encoded by the OCLN gene. Occludin is a 65-kDa (522-amino acid polypeptide -human) integral plasma-membrane protein located at the tight junctions, described for the first time in 1993 by Shoichiro Tsukita. Together with the Claudin group of proteins, it is the main component of the tight junctions.

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