Janus kinase 2

JAK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AEP, 2B7A, 2W1I, 2XA4, 3E62, 3E63, 3E64, 3FUP, 3IO7, 3IOK, 3JY9, 3KCK, 3KRR, 3LPB, 3Q32, 3RVG, 3TJC, 3TJD, 3UGC, 3ZMM, 4AQC, 4BBE, 4BBF, 4C61, 4C62, 4D0W, 4D0X, 4D1S, 4E4M, 4E6D, 4E6Q, 4F08, 4F09, 4FVP, 4FVQ, 4FVR, 4GFM, 4GMY, 4HGE, 4IVA, 4JI9, 4JIA, 4P7E, 4ZIM, 4YTC, 4YTF, 4YTH, 4YTI, 5CF4, 5CF5, 5CF6, 5CF8, 5I4N, 4Z32, 5L3A
Identifiers
Aliases	JAK2, JTK10, THCYT3, Janus kinase 2
External IDs	OMIM: 147796 MGI: 96629 HomoloGene: 21033 GeneCards: JAK2
Genetically Related Diseases
Crohn's disease,
Targeted by Drug
Baricitinib, momelotinib, pacritinib, ruxolitinib
Gene ontology Molecular function • type 1 angiotensin receptor binding • SH2 domain binding • kinase activity • protein C-terminus binding • receptor binding • ATP binding • protein kinase activity • growth hormone receptor binding • acetylcholine receptor binding • interleukin-12 receptor binding • metal ion binding • peptide hormone receptor binding • heme binding • insulin receptor substrate binding • histone kinase activity (H3-Y41 specific) • transferase activity • histone binding • protein binding • protein tyrosine kinase activity • protein kinase binding • nucleotide binding • phosphatidylinositol 3-kinase binding • Ras guanyl-nucleotide exchange factor activity • non-membrane spanning protein tyrosine kinase activity Cellular component • cytoplasm • cytosol • membrane • extrinsic component of cytoplasmic side of plasma membrane • caveola • cytoskeleton • nucleus • nuclear matrix • endosome lumen • membrane raft • endomembrane system • nucleoplasm • plasma membrane • focal adhesion Biological process • negative regulation of neuron apoptotic process • activation of JAK2 kinase activity • intrinsic apoptotic signaling pathway in response to oxidative stress • movement of cell or subcellular component • adaptive immune response • interferon-gamma-mediated signaling pathway • negative regulation of DNA binding • positive regulation of tyrosine phosphorylation of Stat5 protein • tumor necrosis factor-mediated signaling pathway • positive regulation of tyrosine phosphorylation of Stat3 protein • STAT protein import into nucleus • tyrosine phosphorylation of STAT protein • protein phosphorylation • positive regulation of phosphoprotein phosphatase activity • growth hormone receptor signaling pathway • positive regulation of interleukin-1 beta production • positive regulation of DNA binding • mesoderm development • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of cell proliferation • apoptotic process • regulation of apoptotic process • positive regulation of cell activation • positive regulation of protein import into nucleus, translocation • mammary gland epithelium development • extrinsic apoptotic signaling pathway • axon regeneration • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • response to antibiotic • positive regulation of nitric-oxide synthase biosynthetic process • histone H3-Y41 phosphorylation • response to oxidative stress • response to tumor necrosis factor • response to interleukin-12 • interleukin-12-mediated signaling pathway • positive regulation of cell differentiation • positive regulation of tumor necrosis factor production • positive regulation of peptidyl-tyrosine phosphorylation • erythrocyte differentiation • protein autophosphorylation • platelet-derived growth factor receptor signaling pathway • positive regulation of cell-substrate adhesion • positive regulation of growth hormone receptor signaling pathway • G-protein coupled receptor signaling pathway • cell differentiation • JAK-STAT cascade involved in growth hormone signaling pathway • positive regulation of inflammatory response • phosphorylation • immune system process • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of cardiac muscle cell apoptotic process • actin filament polymerization • response to lipopolysaccharide • regulation of inflammatory response • peptidyl-tyrosine autophosphorylation • tyrosine phosphorylation of Stat3 protein • enzyme linked receptor protein signaling pathway • positive regulation of insulin secretion • JAK-STAT cascade • intracellular signal transduction • negative regulation of cell-cell adhesion • tyrosine phosphorylation of Stat5 protein • mineralocorticoid receptor signaling pathway • negative regulation of heart contraction • positive regulation of cell migration • positive regulation of cytosolic calcium ion concentration • positive regulation of nitric oxide biosynthetic process • blood coagulation • response to hydroperoxide • MAPK cascade • regulation of interferon-gamma-mediated signaling pathway • regulation of cell proliferation • positive regulation of cell proliferation • hormone-mediated signaling pathway • positive regulation of apoptotic process • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • tyrosine phosphorylation of Stat1 protein • cell migration • signal transduction • cytokine-mediated signaling pathway • positive regulation of epithelial cell apoptotic process • positive regulation of GTPase activity • covalent chromatin modification • positive regulation of growth factor dependent skeletal muscle satellite cell proliferation • innate immune response • activation of MAPKK activity • negative regulation of cell death • positive regulation of vascular smooth muscle cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3717	16452
Ensembl	ENSG00000096968	ENSMUSG00000024789
UniProt	O60674	Q62120
RefSeq (mRNA)	NM_004972 NM_001322194 NM_001322195 NM_001322196 NM_001322198 NM_001322199 NM_001322204	NM_001048177 NM_008413
RefSeq (protein)	NP_001309123 NP_001309124 NP_001309125 NP_001309127 NP_001309128 NP_001309133 NP_004963	NP_001041642.1 NP_032439.2 NP_001041642 NP_032439
Location (UCSC)	Chr 9: 4.98 – 5.13 Mb	Chr 19: 29.25 – 29.31 Mb
PubMed search

5AEP, 2B7A, 2W1I, 2XA4, 3E62, 3E63, 3E64, 3FUP, 3IO7, 3IOK, 3JY9, 3KCK, 3KRR, 3LPB, 3Q32, 3RVG, 3TJC, 3TJD, 3UGC, 3ZMM, 4AQC, 4BBE, 4BBF, 4C61, 4C62, 4D0W, 4D0X, 4D1S, 4E4M, 4E6D, 4E6Q, 4F08, 4F09, 4FVP, 4FVQ, 4FVR, 4GFM, 4GMY, 4HGE, 4IVA, 4JI9, 4JIA, 4P7E, 4ZIM, 4YTC, 4YTF, 4YTH, 4YTI, 5CF4, 5CF5, 5CF6, 5CF8, 5I4N, 4Z32, 5L3A

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