HCK

HCK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AD5, 1BU1, 1QCF, 2C0I, 2C0O, 2C0T, 2HCK, 2HK5, 2OI3, 2OJ2, 3HCK, 3NHN, 3RBB, 3REA, 3REB, 3VRY, 3VRZ, 3VS0, 3VS1, 3VS2, 3VS3, 3VS4, 3VS5, 3VS6, 3VS7, 4HCK, 4LUD, 4LUE, 4ORZ, 4U5W, 5HCK
Identifiers
Aliases	HCK, JTK9, p59Hck, p61Hck, HCK proto-oncogene, Src family tyrosine kinase
External IDs	MGI: 96052 HomoloGene: 20489 GeneCards: HCK
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • kinase activity • protein binding • receptor binding • ATP binding • protein tyrosine kinase activity Cellular component • cytoplasm • cytosol • Golgi apparatus • cell projection • membrane • focal adhesion • extrinsic component of cytoplasmic side of plasma membrane • transport vesicle • cell junction • actin filament • caveola • lysosome • cytoskeleton • cytoplasmic vesicle • nucleus • nucleoplasm • plasma membrane Biological process • cell differentiation • leukocyte migration involved in immune response • positive regulation of actin filament polymerization • Fc-gamma receptor signaling pathway involved in phagocytosis • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • cytokine-mediated signaling pathway • interferon-gamma-mediated signaling pathway • immune system process • leukocyte degranulation • negative regulation of apoptotic process • regulation of defense response to virus by virus • protein phosphorylation • cell adhesion • respiratory burst after phagocytosis • regulation of sequence-specific DNA binding transcription factor activity • positive regulation of cell proliferation • regulation of inflammatory response • regulation of cell shape • regulation of podosome assembly • peptidyl-tyrosine autophosphorylation • phagocytosis • integrin-mediated signaling pathway • protein autophosphorylation • peptidyl-tyrosine phosphorylation • regulation of phagocytosis • mesoderm development • inflammatory response • innate immune response-activating signal transduction • positive regulation of actin cytoskeleton reorganization • lipopolysaccharide-mediated signaling pathway • exocytosis • viral process • innate immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3055	15162
Ensembl	ENSG00000101336	ENSMUSG00000003283
UniProt	P08631	P08103
RefSeq (mRNA)	NM_002110 NM_001172129 NM_001172130 NM_001172131 NM_001172132 NM_001172133	NM_001172117 NM_010407
RefSeq (protein)	NP_001165600 NP_001165601 NP_001165602 NP_001165603 NP_001165604 NP_002101	NP_001165588.1 NP_034537.2 NP_001165588 NP_034537
Location (UCSC)	Chr 20: 32.05 – 32.1 Mb	Chr 2: 153.11 – 153.15 Mb
PubMed search

1AD5, 1BU1, 1QCF, 2C0I, 2C0O, 2C0T, 2HCK, 2HK5, 2OI3, 2OJ2, 3HCK, 3NHN, 3RBB, 3REA, 3REB, 3VRY, 3VRZ, 3VS0, 3VS1, 3VS2, 3VS3, 3VS4, 3VS5, 3VS6, 3VS7, 4HCK, 4LUD, 4LUE, 4ORZ, 4U5W, 5HCK

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