Lck

LCK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BHF, 1BHH, 1CWD, 1CWE, 1FBZ, 1H92, 1IJR, 1KIK, 1LCJ, 1LCK, 1LKK, 1LKL, 1Q68, 1Q69, 1QPC, 1QPD, 1QPE, 1QPJ, 1X27, 2IIM, 2OF2, 2OF4, 2OFU, 2OFV, 2OG8, 2PL0, 2ZM1, 2ZM4, 2ZYB, 3AC1, 3AC2, 3AC3, 3AC4, 3AC5, 3AC8, 3ACJ, 3ACK, 3AD4, 3AD5, 3AD6, 3B2W, 3BRH, 3BYM, 3BYO, 3BYS, 3BYU, 3KMM, 3KXZ, 3LCK, 3MPM, 4D8K, 4C3F
Identifiers
Aliases	LCK, LCK proto-oncogene, Src family tyrosine kinase, IMD22, LSK, YT16, p56lck, pp58lck
External IDs	OMIM: 153390 MGI: 96756 HomoloGene: 3911 GeneCards: LCK
Targeted by Drug
saracatinib, SU6656
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • CD4 receptor binding • ATPase binding • SH2 domain binding • glycoprotein binding • CD8 receptor binding • phosphatidylinositol 3-kinase binding • protein C-terminus binding • protein binding • identical protein binding • protein phosphatase binding • ATP binding • protein kinase binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • protein tyrosine kinase activity • kinase activity • protein serine/threonine phosphatase activity • non-membrane spanning protein tyrosine kinase activity Cellular component • cytoplasm • cytosol • membrane • extrinsic component of cytoplasmic side of plasma membrane • immunological synapse • extracellular exosome • pericentriolar material • membrane raft • plasma membrane Biological process • B cell receptor signaling pathway • release of sequestered calcium ion into cytosol • hemopoiesis • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of T cell receptor signaling pathway • T cell costimulation • regulation of defense response to virus by virus • platelet activation • T cell differentiation • regulation of cell proliferation • cellular zinc ion homeostasis • regulation of lymphocyte activation • peptidyl-tyrosine autophosphorylation • T cell receptor signaling pathway • positive regulation of intrinsic apoptotic signaling pathway • phosphatidylinositol-mediated signaling • leukocyte migration • positive regulation of T cell activation • protein dephosphorylation • regulation of phosphatidylinositol 3-kinase signaling • innate immune response • phosphatidylinositol phosphorylation • viral process • protein phosphorylation • activation of cysteine-type endopeptidase activity involved in apoptotic process • response to drug • cell migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3932	16818
Ensembl	ENSG00000182866	ENSMUSG00000000409
UniProt	P06239	P06240
RefSeq (mRNA)	NM_001042771 NM_005356 NM_001330468	NM_001162432 NM_001162433 NM_010693
RefSeq (protein)	NP_001036236 NP_001317397 NP_005347	NP_001155905.1 NP_034823.1 NP_001155904 NP_001155905 NP_034823
Location (UCSC)	Chr 1: 32.25 – 32.29 Mb	Chr 4: 129.55 – 129.57 Mb
PubMed search

1BHF, 1BHH, 1CWD, 1CWE, 1FBZ, 1H92, 1IJR, 1KIK, 1LCJ, 1LCK, 1LKK, 1LKL, 1Q68, 1Q69, 1QPC, 1QPD, 1QPE, 1QPJ, 1X27, 2IIM, 2OF2, 2OF4, 2OFU, 2OFV, 2OG8, 2PL0, 2ZM1, 2ZM4, 2ZYB, 3AC1, 3AC2, 3AC3, 3AC4, 3AC5, 3AC8, 3ACJ, 3ACK, 3AD4, 3AD5, 3AD6, 3B2W, 3BRH, 3BYM, 3BYO, 3BYS, 3BYU, 3KMM, 3KXZ, 3LCK, 3MPM, 4D8K, 4C3F

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