NOV (gene)

NOV
Identifiers
Aliases	NOV, CCN3, IBP-9, IGFBP-9, IGFBP9, NOVh, nephroblastoma overexpressed
External IDs	MGI: 109185 HomoloGene: 1884 GeneCards: NOV
Gene location (Human) Chr. Chromosome 8 (human) Band n/a Start 119,416,306 bp End 119,424,353 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band n/a Start 54,745,702 bp End 54,754,039 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • insulin-like growth factor binding • Notch binding • integrin binding • protein binding • growth factor activity • heparin binding Cellular component • cytoplasm • intracellular membrane-bounded organelle • extracellular matrix • extracellular region • axon • neuronal cell body • cell junction • dendrite • gap junction • extracellular space • proteinaceous extracellular matrix Biological process • fibroblast migration • hematopoietic stem cell homeostasis • negative regulation of insulin secretion • chondrocyte differentiation • negative regulation of sensory perception of pain • smooth muscle cell migration • negative regulation of SMAD protein import into nucleus • endothelial cell-cell adhesion • negative regulation of chondrocyte proliferation • bone regeneration • negative regulation of monocyte chemotaxis • cell adhesion mediated by integrin • negative regulation of cell growth • regulation of cell growth • angiogenesis • endothelial cell chemotaxis • negative regulation of myotube differentiation • cell chemotaxis • regulation of gene expression • smooth muscle cell proliferation • negative regulation of NF-kappaB import into nucleus • negative regulation of inflammatory response • type B pancreatic cell proliferation • positive regulation of Notch signaling pathway • cell-cell signaling • negative regulation of cell death Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4856	18133
Ensembl	ENSG00000136999	ENSMUSG00000037362
UniProt	P48745	Q64299
RefSeq (mRNA)	NM_002514	NM_010930
RefSeq (protein)	NP_002505	NP_035060
Location (UCSC)	Chr 8: 119.42 – 119.42 Mb	Chr 8: 54.75 – 54.75 Mb
PubMed search

4856

18133

ENSG00000136999

ENSMUSG00000037362

P48745

Q64299

NM_002514

NM_010930

NP_002505

NP_035060

NOV (nephroblastoma overexpressed) also known as CCN3 is a matricellular protein that in humans is encoded by the NOV gene.

NOV is a member of the CCN family of secreted, extracellular matrix (ECM)-associated signaling proteins (see also CCN intercellular signaling protein). The CCN acronym is derived from the first three members of the family being identified, namely CYR61 (cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV. These proteins, together with WISP1 (CCN4), WISP2 (CCN5), and WISP3 (CCN6) comprise the six-member CCN family in vertebrates and have been renamed CCN1-6 in the order of their discovery by international consensus.

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Wikipedia