WISP1

WISP1
Identifiers
Aliases	WISP1, CCN4, WISP1c, WISP1i, WISP1tc, WNT1 inducible signaling pathway protein 1
External IDs	MGI: 1197008 HomoloGene: 2883 GeneCards: WISP1
Gene location (Human) Chr. Chromosome 8 (human) Band n/a Start 133,191,039 bp End 133,230,344 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band n/a Start 66,891,320 bp End 66,923,201 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • insulin-like growth factor binding • integrin binding • heparin binding Cellular component • extracellular region • extracellular space • cytosol • proteinaceous extracellular matrix Biological process • Wnt signaling pathway • regulation of cell growth • signal transduction • cell-cell signaling • cell adhesion • negative regulation of cell death Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8840	22402
Ensembl	ENSG00000104415	ENSMUSG00000005124
UniProt	O95388	O54775
RefSeq (mRNA)	NM_001204869 NM_001204870 NM_003882 NM_080838	NM_018865
RefSeq (protein)	NP_001191798 NP_001191799 NP_003873 NP_543028	NP_061353
Location (UCSC)	Chr 8: 133.19 – 133.23 Mb	Chr 8: 66.89 – 66.92 Mb
PubMed search

8840

22402

ENSG00000104415

ENSMUSG00000005124

O95388

O54775

NM_001204869
NM_001204870
NM_003882
NM_080838

NM_018865

NP_001191798
NP_001191799
NP_003873
NP_543028

NP_061353

WNT1-inducible-signaling pathway protein 1 (WISP-1), also known as CCN4, is a matricellular protein that in humans is encoded by the WISP1 gene.

WISP-1 is highly homologous to CYR61 (CCN1) and CTGF (CCN2), and is a member of the CCN family of secreted, extracellular matrix (ECM)-associated signaling proteins (CCN intercellular signaling protein). The CCN family of proteins shares a common molecular protein structure, characterized by an N-terminal secretory signal peptide followed by four distinct domains with homologies to insulin-like growth factor binding protein (IGFBP), von Willebrand type C repeats (vWC), thrombospondin type 1 repeat (TSR), and a cysteine knot motif within the C-terminal (CT) domain. This family of proteins regulates diverse cellular functions, including cell adhesion, migration, proliferation, differentiation, and survival.

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