CTGF

CTGF
Identifiers
Aliases	CTGF, CCN2, HCS24, IGFBP8, NOV2, connective tissue growth factor
External IDs	OMIM: 121009 MGI: 95537 HomoloGene: 1431 GeneCards: CTGF
Gene ontology Molecular function • fibronectin binding • insulin-like growth factor binding • protein C-terminus binding • protein binding • growth factor activity • integrin binding • heparin binding Cellular component • cytosol • Golgi apparatus • intracellular membrane-bounded organelle • proteinaceous extracellular matrix • cis-Golgi network • plasma membrane • extracellular region • cell cortex • perinuclear region of cytoplasm • extracellular space Biological process • positive regulation of collagen biosynthetic process • positive regulation of cell activation • cell differentiation • regulation of chondrocyte differentiation • response to amino acid • response to estradiol • response to anoxia • intracellular signal transduction • response to mineralocorticoid • response to fatty acid • DNA biosynthetic process • positive regulation of cell death • ossification • response to organic cyclic compound • extracellular matrix constituent secretion • lung development • response to peptide hormone • positive regulation of G0 to G1 transition • positive regulation of JNK cascade • response to glucose • negative regulation of gene expression • reactive oxygen species metabolic process • fibroblast growth factor receptor signaling pathway • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of gene expression • connective tissue development • response to wounding • regulation of cell growth • angiogenesis • tissue homeostasis • positive regulation of cell proliferation • chondrocyte proliferation • positive regulation of cell differentiation • epidermis development • positive regulation of cardiac muscle contraction • positive regulation of ERK1 and ERK2 cascade • positive regulation of protein phosphorylation • integrin-mediated signaling pathway • transcription initiation from RNA polymerase II promoter • cell-matrix adhesion • cell migration • cartilage condensation • positive regulation of stress fiber assembly • cytosolic calcium ion transport • aging • cell adhesion • negative regulation of cell death Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1490	14219
Ensembl	ENSG00000118523	ENSMUSG00000019997
UniProt	P29279	P29268
RefSeq (mRNA)	NM_001901	NM_010217
RefSeq (protein)	NP_001892	NP_034347.2 NP_034347
Location (UCSC)	Chr 6: 131.95 – 131.95 Mb	Chr 10: 24.6 – 24.6 Mb
PubMed search

1490

14219

ENSG00000118523

ENSMUSG00000019997

P29279

P29268

NM_001901

NM_010217

NP_001892

NP_034347.2
NP_034347

CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is critically involved in fibrotic disease and several forms of cancers.

Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved, cysteine-rich domains. These domains are, from N- to C-termini, the insulin-like growth factor binding protein (IGFBP) domain, the von Willebrand type C repeats (vWC) domain, the thrombospondin type 1 repeat (TSR) domain, and a C-terminal domain (CT) with a cysteine knot motif. CTGF exerts its functions by binding to various cell surface receptors in a context-dependent manner, including integrin receptors, cell surface heparan sulfate proteoglycans (HSPGs),LRPs, and TrkA. In addition, CTGF also binds growth factors and extracellular matrix proteins. The N-terminal half of CTGF interacts with aggrecan, the TSR domain interacts with VEGF, and the CT domain interacts with members of the TGF-β superfamily, fibronectin, perlecan, fibulin-1, slit, and mucins.

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