Aggrecan

ACAN
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4MD4
Identifiers
Aliases	ACAN, AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK, Aggrecan
External IDs	HomoloGene: 136177 GeneCards: ACAN
Gene ontology Molecular function • extracellular matrix structural constituent • metal ion binding • protein binding • hyaluronic acid binding • carbohydrate binding Cellular component • extracellular matrix • proteinaceous extracellular matrix • extracellular region • lysosomal lumen • Golgi lumen Biological process • skeletal system development • extracellular matrix disassembly • extracellular matrix organization • proteolysis • central nervous system development • keratan sulfate catabolic process • keratan sulfate biosynthetic process • cell adhesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	176	n/a
Ensembl	ENSG00000157766	n/a
UniProt	P16112	n/a
RefSeq (mRNA)	NM_001135 NM_013227	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr 15: 88.8 – 88.88 Mb	n/a
PubMed search		n/a

4MD4

176

n/a

ENSG00000157766

n/a

P16112

n/a

NM_001135
NM_013227

n/a

n/a

n/a

Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. This gene is a member of the lectican (chondroitin sulfate proteoglycan) family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage.

Aggrecan is a proteoglycan, or a protein modified with large carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing.

Aggrecan is a high molecular weight (1x10⁶ < M < 3x10⁶) proteoglycan. It exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate glycosaminoglycan (GAG) chains are attached to an extended protein core.

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