Fibronectin

FN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6, 1TTF, 1TTG, 2CG6, 2CG7, 2CK2, 2CKU, 2EC3, 2FN2, 2FNB, 2GEE, 2H41, 2H45, 2HA1, 2OCF, 2RKY, 2RKZ, 2RL0, 3CAL, 3EJH, 3GXE, 3M7P, 3MQL, 3R8Q, 3ZRZ, 4GH7, 4JE4, 4JEG, 4LXO, 4MMX, 4MMY, 4MMZ, 4PZ5, 2N1K, 5DC4, 5DC0, 5DC9, 3T1W
Identifiers
Aliases	FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1
External IDs	OMIM: 135600 MGI: 95566 HomoloGene: 1533 GeneCards: FN1
Gene ontology Molecular function • heparin binding • collagen binding • integrin binding • protein binding • identical protein binding • peptidase activator activity • protease binding Cellular component • blood microparticle • extracellular matrix • proteinaceous extracellular matrix • fibrinogen complex • basal lamina • extracellular region • basement membrane • apical plasma membrane • extracellular exosome • platelet alpha granule lumen • endoplasmic reticulum-Golgi intermediate compartment • Biological process • regulation of protein phosphorylation • calcium-independent cell-matrix adhesion • endodermal cell differentiation • positive regulation of fibroblast proliferation • positive regulation of substrate-dependent cell migration, cell attachment to substrate • negative regulation of transforming growth factor-beta secretion • platelet degranulation • extracellular matrix disassembly • wound healing • positive regulation of peptidase activity • peptide cross-linking • cell adhesion • positive regulation of gene expression • acute-phase response • angiogenesis • positive regulation of cell proliferation • regulation of cell shape • regulation of ERK1 and ERK2 cascade • cell-substrate junction assembly • substrate adhesion-dependent cell spreading • integrin activation • positive regulation of axon extension • cell-matrix adhesion • leukocyte migration • response to wounding • extracellular matrix organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2335	14268
Ensembl	ENSG00000115414	ENSMUSG00000026193
UniProt	P02751	P11276
RefSeq (mRNA)	NM_001306129 NM_001306130 NM_001306131 NM_001306132 NM_002026 NM_054034 NM_212474 NM_212475 NM_212476 NM_212478 NM_212482	NM_001276408 NM_001276409 NM_001276410 NM_001276411 NM_001276412 NM_001276413 NM_010233
RefSeq (protein)	NP_001293058 NP_001293059 NP_001293060 NP_001293061 NP_002017 NP_473375 NP_997639 NP_997641 NP_997643 NP_997647 NP_001293058.1 NP_001293059.1 NP_001293061.1	NP_034363.1 NP_001263337 NP_001263338 NP_001263339 NP_001263340 NP_001263341 NP_001263342 NP_034363
Location (UCSC)	Chr 2: 215.36 – 215.44 Mb	Chr 1: 71.59 – 71.65 Mb
PubMed search

1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6, 1TTF, 1TTG, 2CG6, 2CG7, 2CK2, 2CKU, 2EC3, 2FN2, 2FNB, 2GEE, 2H41, 2H45, 2HA1, 2OCF, 2RKY, 2RKZ, 2RL0, 3CAL, 3EJH, 3GXE, 3M7P, 3MQL, 3R8Q, 3ZRZ, 4GH7, 4JE4, 4JEG, 4LXO, 4MMX, 4MMY, 4MMZ, 4PZ5, 2N1K, 5DC4, 5DC0, 5DC9, 3T1W

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