Perlecan

HSPG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SH4, 3SH5
Identifiers
Aliases	HSPG2, HSPG, PLC, PRCAN, SJA, SJS, SJS1, heparan sulfate proteoglycan 2
External IDs	OMIM: 142461 MGI: 96257 HomoloGene: 68473 GeneCards: HSPG2
Gene ontology Molecular function • metal ion binding • protein binding • calcium ion binding • protein C-terminus binding Cellular component • basement membrane • Golgi lumen • extracellular exosome • lysosomal lumen • extracellular region • plasma membrane • proteinaceous extracellular matrix • extracellular matrix • focal adhesion • extracellular space Biological process • glycosaminoglycan metabolic process • extracellular matrix disassembly • cellular protein metabolic process • retinoid metabolic process • glycosaminoglycan biosynthetic process • glycosaminoglycan catabolic process • angiogenesis • extracellular matrix organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3339	15530
Ensembl	ENSG00000142798	ENSMUSG00000028763
UniProt	P98160	Q05793
RefSeq (mRNA)	NM_001291860 NM_005529	NM_008305
RefSeq (protein)	NP_001278789 NP_005520	NP_032331.2 NP_032331
Location (UCSC)	Chr 1: 21.82 – 21.94 Mb	Chr 4: 137.47 – 137.57 Mb
PubMed search

3SH4, 3SH5

3339

15530

ENSG00000142798

ENSMUSG00000028763

P98160

Q05793

NM_001291860
NM_005529

NM_008305

NP_001278789
NP_005520

NP_032331.2
NP_032331

Perlecan (PLC) also known as basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) or heparan sulfate proteoglycan 2 (HSPG2), is a protein that in humans is encoded by the HSPG2 gene.

Perlecan is a large multidomain (five domains, labeled I-V) proteoglycan that binds to and cross-links many extracellular matrix (ECM) components and cell-surface molecules. Perlecan is synthesized by both vascular endothelial and smooth muscle cells and deposited in the extracellular matrix. Perlecan is highly conserved across species and the available data indicate that it has evolved from ancient ancestors by gene duplication and exon shuffling.

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Wikipedia