CYR61

CYR61
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D0Z, 4D11
Identifiers
Aliases	CYR61, CCN1, GIG1, IGFBP10, cysteine rich angiogenic inducer 61
External IDs	MGI: 88613 HomoloGene: 1194 GeneCards: CYR61
Gene location (Human) Chr. Chromosome 1 (human) Band n/a Start 85,580,761 bp End 85,583,962 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band n/a Start 145,646,976 bp End 145,649,981 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • insulin-like growth factor binding • growth factor binding • extracellular matrix binding • integrin binding • heparin binding Cellular component • extracellular matrix • extracellular region • extracellular space • endoplasmic reticulum lumen • proteinaceous extracellular matrix Biological process • positive regulation of osteoblast proliferation • single organismal cell-cell adhesion • apoptotic process involved in heart morphogenesis • positive regulation of ceramide biosynthetic process • positive regulation of protein phosphorylation • ventricular septum development • positive regulation of cell migration • anatomical structure morphogenesis • extracellular matrix organization • negative regulation of apoptotic process • labyrinthine layer blood vessel development • reactive oxygen species metabolic process • chorio-allantoic fusion • chondroblast differentiation • chemotaxis • positive regulation of phospholipase activity • atrial septum morphogenesis • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • intussusceptive angiogenesis • positive regulation of osteoblast differentiation • atrioventricular valve morphogenesis • positive regulation of cartilage development • regulation of cell growth • osteoblast differentiation • positive regulation of cell differentiation • regulation of ERK1 and ERK2 cascade • positive regulation of BMP signaling pathway • positive regulation of apoptotic process • cell proliferation • wound healing, spreading of cells • positive regulation of transcription from RNA polymerase II promoter • positive regulation of protein kinase activity • positive regulation of cell-substrate adhesion • post-translational protein modification • cellular protein metabolic process • cell adhesion • cell-cell signaling • negative regulation of cell death Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3491	16007
Ensembl	ENSG00000142871	ENSMUSG00000028195
UniProt	O00622	P18406
RefSeq (mRNA)	NM_001554	NM_010516
RefSeq (protein)	NP_001545	NP_034646
Location (UCSC)	Chr 1: 85.58 – 85.58 Mb	Chr 1: 145.65 – 145.65 Mb
PubMed search

4D0Z, 4D11

3491

16007

ENSG00000142871

ENSMUSG00000028195

O00622

P18406

NM_001554

NM_010516

NP_001545

NP_034646

Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene.

CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). CYR61 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. In adulthood CYR61 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers.

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