WISP3

Identifiers

WISP3, CCN6, LIBC, PPAC, PPD, WISP-3, WNT1 inducible signaling pathway protein 3

External IDs

MGI: 2685581 HomoloGene: 77038 GeneCards: WISP3

Gene location (Human)

Chr.	Chromosome 6 (human)

Band	n/a	Start	112,054,072 bp
Band	n/a	End	112,070,969 bp

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)

Band	n/a	Start	39,150,970 bp
Band	n/a	End	39,163,794 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• insulin-like growth factor binding • growth factor activity • integrin binding • heparin binding
Cellular component	• extracellular region • extracellular space • proteinaceous extracellular matrix
Biological process	• cell-cell signaling • regulation of cell growth • signal transduction • cell adhesion • negative regulation of cell death
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8838


327743

Ensembl


ENSG00000112761


ENSMUSG00000062074

UniProt


O95389


D3Z5L9

RefSeq (mRNA)


NM_003880 NM_130396 NM_198239


NM_001127376

RefSeq (protein)


NP_003871 NP_937882


NP_001120848

Location (UCSC)

Chr 6: 112.05 – 112.07 Mb

Chr 6: 39.15 – 39.16 Mb

PubMed search

NM_003880
NM_130396
NM_198239

NM_001127376

NP_003871
NP_937882

NP_001120848

WNT1-inducible-signaling pathway protein 3 (WISP3, also named CCN6) is a matricellular protein that in humans is encoded by the WISP3 gene.

It is a member of the CCN family (CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated signaling matricellular proteins. The CCN acronym is derived from the first three members of the family identified, namely CYR61 (cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV (nephroblastoma overexpressed, or CCN3). These proteins, together with WISP1 (CCN4), and WISP2 (CCN5) comprise the six-member CCN family in vertebrates. CCN proteins characteristically contain an N-terminal secretory signal peptide followed by four structurally distinct domains with homologies to insulin-like growth factor binding protein (IGFBP), von Willebrand type C repeats (vWC), thrombospondin type 1 repeat (TSR), and a cysteine knot motif within the C-terminal (CT) domain.

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