Inhibitor of apoptosis domain
| Inhibitor of Apoptosis domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
NMR solution structure of the BIR domain of human BIRC2 protein. The protein is rainbow colored cartoon diagram (N-terminus = blue, C-terminus = red) while the coordinated zinc is represented by a grey sphere.
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| Identifiers | |||||||||
| Symbol | BIR | ||||||||
| Pfam | PF00653 | ||||||||
| InterPro | IPR001370 | ||||||||
| PROSITE | PS50143 | ||||||||
| SCOP | 1qbh | ||||||||
| SUPERFAMILY | 1qbh | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation. Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6.
BIR domains belong to the zinc-finger domain family and characteristically have a number of invariant amino acid residues, including 3 conserved cysteines and one conserved histidine, which coordinate a zinc ion. They are typically composed of 4-5 alpha helices and a three-stranded beta sheet.
This article incorporates text from the public domain Pfam and InterPro IPR001370
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