Survivin

BIRC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E31, 1F3H, 1XOX, 2QFA, 2RAW, 2RAX, 3UEC, 3UED, 3UEE, 3UEF, 3UEG, 3UEH, 3UEI, 3UIG, 3UIH, 3UII, 3UIJ, 3UIK, 4A0I, 4A0J, 4A0N
Identifiers
Aliases	BIRC5, API4, EPR-1, baculoviral IAP repeat containing 5
External IDs	OMIM: 603352 MGI: 1203517 HomoloGene: 37450 GeneCards: BIRC5
Gene ontology Molecular function • peptidase inhibitor activity • cobalt ion binding • chaperone binding • protein homodimerization activity • Ran GTPase binding • metal ion binding • ubiquitin-protein transferase activity • tubulin binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • protein binding • cofactor binding • identical protein binding • protein heterodimerization activity • enzyme binding • microtubule binding • zinc ion binding • cysteine-type endopeptidase inhibitor activity Cellular component • cytosol • spindle • chromosome • nucleoplasm • chromosome passenger complex • nuclear chromosome • interphase microtubule organizing center • spindle microtubule • centriole • cytoplasmic microtubule • cytoskeleton • microtubule • kinetochore • condensed chromosome kinetochore • midbody • cytoplasm • chromosome, centromeric region • nucleus Biological process • negative regulation of peptidase activity • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of transcription, DNA-templated • inhibition of cysteine-type endopeptidase activity involved in apoptotic process • establishment of chromosome localization • chromosome segregation • positive regulation of mitotic cell cycle • positive regulation of exit from mitosis • cytokinesis • protein sumoylation • transcription, DNA-templated • cell division • protein phosphorylation • spindle checkpoint • mitotic spindle assembly • regulation of signal transduction • G2/M transition of mitotic cell cycle • positive regulation of cell proliferation • protein complex localization • cell cycle • negative regulation of transcription, DNA-templated • apoptotic process • sister chromatid cohesion • protein ubiquitination • regulation of apoptotic process • negative regulation of apoptotic process • regulation of mitotic cell cycle • mitotic cell cycle Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	332	11799
Ensembl	ENSG00000089685	ENSMUSG00000017716
UniProt	O15392	O70201
RefSeq (mRNA)	NM_001012270 NM_001012271 NM_001168	NM_001012272 NM_001012273 NM_009689
RefSeq (protein)	NP_001012270 NP_001012271 NP_001159	NP_001012273.1 NP_033819.1 NP_001012273 NP_033819
Location (UCSC)	Chr 17: 78.21 – 78.23 Mb	Chr 11: 117.85 – 117.86 Mb
PubMed search

1E31, 1F3H, 1XOX, 2QFA, 2RAW, 2RAX, 3UEC, 3UED, 3UEE, 3UEF, 3UEG, 3UEH, 3UEI, 3UIG, 3UIH, 3UII, 3UIJ, 3UIK, 4A0I, 4A0J, 4A0N

332

11799

ENSG00000089685

ENSMUSG00000017716

...
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