BIRC6

BIRC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CEG
Identifiers
Aliases	BIRC6, APOLLON, BRUCE, baculoviral IAP repeat containing 6
External IDs	MGI: 1276108 HomoloGene: 7248 GeneCards: BIRC6
Gene location (Human) Chr. Chromosome 2 (human) Band 2p22.3 Start 32,357,028 bp End 32,618,899 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band n/a Start 74,528,295 bp End 74,703,356 bp
Gene ontology Molecular function • peptidase inhibitor activity • cysteine-type endopeptidase inhibitor activity • ubiquitin-protein transferase activity • protein binding • ubiquitin conjugating enzyme activity • transferase activity Cellular component • cytoplasm • endosome • spindle pole • membrane • microtubule organizing center • trans-Golgi network • midbody • cytoskeleton • Golgi apparatus • intracellular membrane-bounded organelle Biological process • negative regulation of peptidase activity • spongiotrophoblast layer development • regulation of cytokinesis • placenta development • labyrinthine layer development • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of apoptotic process • cell division • protein phosphorylation • regulation of cell proliferation • protein ubiquitination • positive regulation of cell proliferation • cell cycle • apoptotic process • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57448	12211
Ensembl	ENSG00000115760	ENSMUSG00000024073
UniProt	Q9NR09	O88738
RefSeq (mRNA)	NM_016252	NM_007566
RefSeq (protein)	NP_057336	NP_031592
Location (UCSC)	Chr 2: 32.36 – 32.62 Mb	Chr 2: 74.53 – 74.7 Mb
PubMed search

3CEG

57448

12211

ENSG00000115760

ENSMUSG00000024073

Q9NR09

O88738

NM_016252

NM_007566

NP_057336

NP_031592

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.

BIRC6 has been shown to interact with KIF23.

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology).

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