KIF23

KIF23
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VHX
Identifiers
Aliases	KIF23, CHO1, KNSL5, MKLP-1, MKLP1, kinesin family member 23
External IDs	MGI: 1919069 HomoloGene: 11491 GeneCards: KIF23
Gene ontology Molecular function • nucleotide binding • microtubule binding • ATPase activity • protein binding • ATP binding • microtubule motor activity Cellular component • cytoplasm • cytosol • centrosome • centralspindlin complex • kinesin complex • focal adhesion • spindle • nucleoplasm • midbody • intercellular bridge • mitotic spindle • microtubule • cytoskeleton • nucleus Biological process • plus-end-directed vesicle transport along microtubule • antigen processing and presentation of exogenous peptide antigen via MHC class II • mitotic spindle midzone assembly • mitotic cytokinesis • cytokinesis • cell division • positive regulation of cytokinesis • microtubule-based movement • actomyosin contractile ring assembly • cell cycle • mitotic spindle elongation • retrograde vesicle-mediated transport, Golgi to ER Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9493	71819
Ensembl	ENSG00000137807	ENSMUSG00000032254
UniProt	Q02241	E9Q5G3
RefSeq (mRNA)	NM_001281301 NM_004856 NM_138555	NM_024245
RefSeq (protein)	NP_001268230 NP_004847 NP_612565	NP_077207.3 NP_077207
Location (UCSC)	Chr 15: 69.41 – 69.45 Mb	Chr 9: 61.92 – 61.95 Mb
PubMed search

3VHX

9493

71819

ENSG00000137807

ENSMUSG00000032254

Q02241

E9Q5G3

NM_001281301
NM_004856
NM_138555

NM_024245

NP_001268230
NP_004847
NP_612565

NP_077207.3
NP_077207

Kinesin-like protein KIF23 is a protein that in humans is encoded by the KIF23 gene.

KIF23 (also known as Kinesin-6, CHO1/MKLP1, C. elegans ZEN-4 and Drosophila Pavarotti) is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different isoforms, better known as CHO1, the larger isoform and MKLP1, the smaller isoform. KIF23 is a plus-end directed motor protein expressed in mitosis, involved in the formation of the cleavage furrow in late anaphase and in cytokinesis. KIF23 is part of the centralspindlin complex that includes PRC1, Aurora B and 14-3-3 which cluster together at the spindle midzone to enable anaphase in dividing cells.

...
Wikipedia