Aurora B

AURKB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AF3
Identifiers
Aliases	AURKB, AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5, aurkb-sv1, aurkb-sv2, aurora kinase B
External IDs	OMIM: 604970 MGI: 107168 HomoloGene: 55807 GeneCards: AURKB
Targeted by Drug
hesperadin, SU6656, tozasertib, zm-447439
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • histone serine kinase activity • metal ion binding • kinase activity • protein binding • protein serine/threonine/tyrosine kinase activity • ATP binding • protein serine/threonine kinase activity Cellular component • cytoplasm • cytosol • spindle • spindle pole centrosome • nucleoplasm • chromosome • chromosome passenger complex • midbody • spindle microtubule • spindle midzone • chromocenter • chromosome, centromeric region • cytoskeleton • nucleus • kinetochore • condensed chromosome, centromeric region • condensed nuclear chromosome, centromeric region • mitotic spindle midzone Biological process • abscission • cleavage furrow formation • positive regulation of telomere capping • phosphorylation • mitotic spindle midzone assembly • histone modification • cellular response to UV • aging • positive regulation of telomere maintenance via telomerase • negative regulation of transcription from RNA polymerase II promoter • negative regulation of protein binding • protein sumoylation • positive regulation of cytokinesis • regulation of chromosome segregation • cell division • protein phosphorylation • spindle checkpoint • positive regulation of telomerase activity • protein autophosphorylation • negative regulation of B cell apoptotic process • negative regulation of cytokinesis • anaphase-promoting complex-dependent catabolic process • cell cycle • cell proliferation • attachment of spindle microtubules to kinetochore • protein localization to kinetochore • histone H3-S28 phosphorylation • spindle organization • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • regulation of signal transduction by p53 class mediator • sister chromatid cohesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9212	20877
Ensembl	ENSG00000178999	ENSMUSG00000020897
UniProt	Q96GD4	O70126
RefSeq (mRNA)	NM_001313950 NM_001313951 NM_001313952 NM_001313953 NM_001313954 NM_001313955 NM_001256834 NM_001284526 NM_004217	NM_011496
RefSeq (protein)	NP_001243763 NP_001271455 NP_001300879 NP_001300880 NP_001300881 NP_001300882 NP_001300883 NP_001300884 NP_004208	NP_035626.1 NP_035626
Location (UCSC)	Chr 17: 8.2 – 8.21 Mb	Chr 11: 69.05 – 69.05 Mb
PubMed search

4AF3

9212

20877

ENSG00000178999

ENSMUSG00000020897

Q96GD4

O70126

NM_001313955
NM_001256834
NM_001284526
NM_004217

NM_011496

NP_001300882
NP_001300883
NP_001300884
NP_004208

NP_035626.1
NP_035626

Aurora B kinase is a protein that functions in the attachment of the mitotic spindle to the centromere.

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Wikipedia