BIRC2

BIRC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QBH, 2L9M, 3D9T, 3D9U, 3M1D, 3MUP, 3OZ1, 3T6P, 3UW4, 4EB9, 4HY4, 4HY5, 4KMN, 4LGE, 4LGU, 4MTI, 4MU7
Identifiers
Aliases	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1, baculoviral IAP repeat containing 2
External IDs	MGI: 1197009 HomoloGene: 900 GeneCards: BIRC2
Gene ontology Molecular function • protein N-terminus binding • transcription coactivator activity • metal ion binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • protein binding • ubiquitin-protein transferase activity • transferase activity • ubiquitin binding • chaperone binding • FBXO family protein binding • zinc ion binding Cellular component • cytosol • XY body • protein complex • membrane raft • CD40 receptor complex • cytoplasmic side of plasma membrane • nucleus • cytoplasm Biological process • regulation of apoptotic process • regulation of nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of protein K63-linked ubiquitination • response to hypoxia • regulation of transcription, DNA-templated • regulation of innate immune response • response to organic cyclic compound • negative regulation of ripoptosome assembly involved in necroptotic process • regulation of toll-like receptor signaling pathway • protein heterooligomerization • inhibition of cysteine-type endopeptidase activity involved in apoptotic process • placenta development • regulation of cysteine-type endopeptidase activity • regulation of RIG-I signaling pathway • regulation of tumor necrosis factor-mediated signaling pathway • protein polyubiquitination • negative regulation of apoptotic process • tumor necrosis factor-mediated signaling pathway • regulation of reactive oxygen species metabolic process • transcription, DNA-templated • regulation of cell cycle • TRIF-dependent toll-like receptor signaling pathway • positive regulation of protein monoubiquitination • mitotic spindle assembly • cell surface receptor signaling pathway • NIK/NF-kappaB signaling • regulation of cell proliferation • response to organonitrogen compound • regulation of inflammatory response • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of cell differentiation • positive regulation of protein K48-linked ubiquitination • response to cAMP • response to ethanol • I-kappaB kinase/NF-kappaB signaling • proteasome-mediated ubiquitin-dependent protein catabolic process • necroptotic process • apoptotic process • protein deubiquitination • regulation of necroptotic process • cellular response to tumor necrosis factor • execution phase of apoptosis • regulation of NIK/NF-kappaB signaling • positive regulation of protein polyubiquitination • negative regulation of necroptotic process • regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	329	11797
Ensembl	ENSG00000110330	ENSMUSG00000057367
UniProt	Q13490	Q62210
RefSeq (mRNA)	NM_001256166 NM_001166 NM_001256163	NM_007465 NM_001291503
RefSeq (protein)	NP_001157 NP_001243092 NP_001243095	NP_001278432 NP_031491
Location (UCSC)	Chr 11: 102.35 – 102.38 Mb	Chr 9: 7.82 – 7.84 Mb
PubMed search

1QBH, 2L9M, 3D9T, 3D9U, 3M1D, 3MUP, 3OZ1, 3T6P, 3UW4, 4EB9, 4HY4, 4HY5, 4KMN, 4LGE, 4LGU, 4MTI, 4MU7

329

11797

ENSG00000110330

ENSMUSG00000057367

Q13490

Q62210

NM_001256166
NM_001166
NM_001256163

...
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