BIRC3

BIRC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2UVL, 3EB5, 3EB6, 3M0A, 3M0D
Identifiers
Aliases	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2, baculoviral IAP repeat containing 3
External IDs	MGI: 1197007 HomoloGene: 899 GeneCards: BIRC3
Gene ontology Molecular function • metal ion binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • protein binding • ubiquitin-protein transferase activity • transferase activity Cellular component • cytoplasm • nucleoplasm • protein complex • membrane raft • nucleus • cytosol Biological process • regulation of apoptotic process • regulation of nucleotide-binding oligomerization domain containing signaling pathway • regulation of innate immune response • regulation of toll-like receptor signaling pathway • protein heterooligomerization • negative regulation of necroptotic process • inhibition of cysteine-type endopeptidase activity involved in apoptotic process • regulation of cysteine-type endopeptidase activity • regulation of RIG-I signaling pathway • regulation of tumor necrosis factor-mediated signaling pathway • negative regulation of apoptotic process • tumor necrosis factor-mediated signaling pathway • TRIF-dependent toll-like receptor signaling pathway • mitotic spindle assembly • cell surface receptor signaling pathway • NIK/NF-kappaB signaling • spermatogenesis • regulation of inflammatory response • positive regulation of I-kappaB kinase/NF-kappaB signaling • I-kappaB kinase/NF-kappaB signaling • positive regulation of protein ubiquitination • apoptotic process • protein ubiquitination • protein deubiquitination • regulation of necroptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	330	11796
Ensembl	ENSG00000023445	ENSMUSG00000032000
UniProt	Q13489	O08863
RefSeq (mRNA)	NM_001165 NM_182962	NM_007464
RefSeq (protein)	NP_001156 NP_892007	NP_031490
Location (UCSC)	Chr 11: 102.32 – 102.34 Mb	Chr 9: 7.85 – 7.87 Mb
PubMed search

2UVL, 3EB5, 3EB6, 3M0A, 3M0D

330

11796

ENSG00000023445

ENSMUSG00000032000

Q13489

O08863

NM_001165
NM_182962

NM_007464

NP_001156
NP_892007

NP_031490

Baculoviral IAP repeat-containing protein3 (also known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene.

cIAP2 is a member of the inhibitor of apoptosis family that inhibit apoptosis by interfering with the activation of caspases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The cIAP2 protein contains three BIR domains, a UBA domain, a CARD domain and a RING finger domain. Transcript variants encoding the same isoform have been identified.

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