*** Welcome to piglix ***

Coumadin

Warfarin
Warfarin.svg
Warfarin ball-and-stick model.png
Clinical data
Pronunciation /ˈwɔːrfəˌrɪn/ WORF-ə-rin
Trade names Coumadin, Jantoven, Marevan, others
AHFS/Drugs.com Monograph
MedlinePlus a682277
License data
Pregnancy
category
  • AU: D
  • US: X (Contraindicated)
Routes of
administration
By mouth or intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 79-100% (by mouth)
Protein binding 99%
Metabolism Liver: CYP2C9, 2C19, 2C8, 2C18, 1A2 and 3A4
Biological half-life 20-60 hours (mean: 40 hours)
Excretion Kidney (92%)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.001.253
Chemical and physical data
Formula C19H16O4
Molar mass 308.33 g/mol
3D model (Jmol)
 NYesY (what is this?)  

Warfarin, sold under the brand name Coumadin among others, is a medication that is used as a blood thinner. It is commonly used to treat blood clots such as deep vein thrombosis and pulmonary embolism and to prevent stroke in people who have atrial fibrillation, valvular heart disease or artificial heart valves. Less commonly it is used following ST-segment elevation myocardial infarction (STEMI) and orthopedic surgery. It is generally taken by mouth but may also be used by injection into a vein.

The common side effect is bleeding. Less common side effects may include tissue death and purple toes syndrome. Use is not generally recommended during pregnancy. It is recommended that the effects of warfarin typically be monitored by checking prothrombin time every one to four weeks. Many other medications and dietary factors can interact with warfarin, either increasing or decreasing its effectiveness. The effects of warfarin may be reversed with phytonadione (vitamin K1), fresh frozen plasma, or prothrombin complex concentrate.

Warfarin decreases blood clotting by blocking the enzyme vitamin K oxide reductase that reactivates vitamin K1. Without sufficient active vitamin K1, clotting factors II, VII, IX, and X have decreased clotting ability. The anticlotting protein C and protein S are also inhibited but to a lesser degree. A few days are required for full effect to occur and these effects can last for up to five days.


...
Wikipedia

...