CYP2C9

CYP2C9
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1OG2, 1OG5, 1R9O, 4NZ2
Identifiers
Aliases	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9, cytochrome P450 family 2 subfamily C member 9, Cytochrome P450 2C9
External IDs	OMIM: 601130 MGI: 1917138 HomoloGene: 133566 GeneCards: CYP2C9
EC number	1.14.13.48
Gene ontology Molecular function • iron ion binding • (R)-limonene 6-monooxygenase activity • (S)-limonene 6-monooxygenase activity • (S)-limonene 7-monooxygenase activity • arachidonic acid epoxygenase activity • metal ion binding • steroid hydroxylase activity • caffeine oxidase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • drug binding • cholesterol 25-hydroxylase activity • oxidoreductase activity • oxygen binding • monooxygenase activity Cellular component • organelle membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • endoplasmic reticulum Biological process • steroid metabolic process • lipid metabolic process • exogenous drug catabolic process • cellular amide metabolic process • epoxygenase P450 pathway • monocarboxylic acid metabolic process • oxidative demethylation • drug catabolic process • omega-hydroxylase P450 pathway • drug metabolic process • monoterpenoid metabolic process • xenobiotic metabolic process • urea metabolic process • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1559	69888
Ensembl	ENSG00000138109	ENSMUSG00000067229
UniProt	P11712	n/a
RefSeq (mRNA)	NM_000771	NM_001011707
RefSeq (protein)	NP_000762	n/a
Location (UCSC)	Chr 10: 94.94 – 94.99 Mb	Chr 19: 39.11 – 39.19 Mb
PubMed search

1OG2, 1OG5, 1R9O, 4NZ2

1559

69888

ENSG00000138109

ENSMUSG00000067229

P11712

n/a

NM_000771

NM_001011707

NP_000762

n/a

Cytochrome P450 2C9 (abbreviated CYP2C9) is an enzyme that in humans is encoded by the CYP2C9 gene.

CYP2C9 is an important enzyme with a major role in the oxidation of both xenobiotic and endogenous compounds. CYP2C9 makes up about 18% of the protein in liver microsomes (data only for antifungal). Some 100 therapeutic drugs are metabolized by CYP2C9, including drugs with a narrow therapeutic index such as warfarin and phenytoin and other routinely prescribed drugs such as acenocoumarol, tolbutamide, losartan, glipizide, and some nonsteroidal anti-inflammatory drugs. By contrast, the known extrahepatic CYP2C9 often metabolizes important endogenous compound such as 5-hydroxytryptamine and, owing to its epoxygenase activity, various polyunsaturated fatty acids, converting these fatty acids to a wide range of biological active products.

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Wikipedia