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Phytonadione

Phytomenadione
Vitamin K1.png
Clinical data
Trade names Mephyton, others
AHFS/Drugs.com Monograph
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
by mouth, subQ, IM, IV
ATC code
Identifiers
Synonyms Vitamin K1, phytonadione, phylloquinone
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
ECHA InfoCard 100.001.422
Chemical and physical data
Formula C31H46O2
Molar mass 450.70 g/mol
3D model (Jmol)

Phytomenadione, also known as vitamin K1 or phylloquinone , is a vitamin found in food and used as a dietary supplement. As a supplement it is used to treat certain bleeding disorders. This includes in warfarin overdose, hemorrhagic disease of the newborn, vitamin K deficiency, and obstructive jaundice. Use is typically recommended by mouth or injection under the skin. Use by injection into a vein or muscle is recommended only when other routes are not possible. When given by injection benefits are seen within two hours.

Common side effects when given by injection include pain at the site of injection and altered taste. Severe allergic reactions may occur with injected into a vein or muscle. It is unclear if use during pregnancy is safe; however, use is likely okay during breastfeeding. It works by supplying a required component for making a number of blood clotting factors. Found sources include green vegetables, vegetable oil, and some fruit.

Phytomenadione was first isolated in 1939. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 0.11 to 1.27 USD for a 10 mg vial. In the United States a course of treatment costs less than 25 USD. In 1943 Edward Doisy and Henrik Dam were given a Nobel Prize for its discovery.


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