CYP1A2

CYP1A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HI4
Identifiers
Aliases	CYP1A2, CP12, P3-450, P450(PA), cytochrome P450 family 1 subfamily A member 2, Cytochrome P450 1A2
External IDs	OMIM: 124060 MGI: 88589 HomoloGene: 68082 GeneCards: CYP1A2
Gene ontology Molecular function • iron ion binding • demethylase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • metal ion binding • caffeine oxidase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • enzyme binding • oxidoreductase activity • aromatase activity • electron carrier activity • oxygen binding • monooxygenase activity Cellular component • organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • membrane • endoplasmic reticulum Biological process • response to immobilization stress • toxin metabolic process • steroid metabolic process • response to estradiol • alkaloid metabolic process • response to organic cyclic compound • lung development • lipid metabolic process • exogenous drug catabolic process • epoxygenase P450 pathway • cellular response to cadmium ion • post-embryonic development • monocarboxylic acid metabolic process • response to organic substance • oxidative deethylation • oxidative demethylation • drug catabolic process • response to lipopolysaccharide • methylation • steroid catabolic process • omega-hydroxylase P450 pathway • dibenzo-p-dioxin metabolic process • heterocycle metabolic process • cellular respiration • cellular aromatic compound metabolic process • regulation of gene expression • hydrogen peroxide biosynthetic process • monoterpenoid metabolic process • drug metabolic process • xenobiotic metabolic process • oxidation-reduction process • response to drug • porphyrin-containing compound metabolic process • toxin biosynthetic process • cellular response to copper ion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1544	13077
Ensembl	ENSG00000140505	ENSMUSG00000032310
UniProt	P05177	P00186
RefSeq (mRNA)	NM_000761	NM_009993
RefSeq (protein)	NP_000752	NP_034123.1 NP_034123
Location (UCSC)	Chr 15: 74.75 – 74.76 Mb	Chr 9: 57.68 – 57.68 Mb
PubMed search

2HI4

1544

13077

ENSG00000140505

ENSMUSG00000032310

P05177

P00186

NM_000761

NM_009993

NP_000752

NP_034123.1
NP_034123

Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene.

CYP1A2 is a member of the superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP1A2 localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.

...
Wikipedia