Protein S

PROS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z6C
Identifiers
Aliases	PROS1, PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6, protein S (alpha)
External IDs	OMIM: 176880 MGI: 1095733 HomoloGene: 264 GeneCards: PROS1
Gene ontology Molecular function • calcium ion binding • endopeptidase inhibitor activity Cellular component • blood microparticle • endoplasmic reticulum membrane • Golgi membrane • plasma membrane • extracellular region • Golgi lumen • extracellular exosome • platelet alpha granule lumen • extracellular space Biological process • hemostasis • fibrinolysis • platelet degranulation • blood coagulation • ER to Golgi vesicle-mediated transport • signal peptide processing • peptidyl-glutamic acid carboxylation • regulation of complement activation • leukocyte migration • negative regulation of endopeptidase activity • negative regulation of blood coagulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5627	19128
Ensembl	ENSG00000184500	ENSMUSG00000022912
UniProt	P07225	Q08761
RefSeq (mRNA)	NM_000313 NM_001314077	NM_011173
RefSeq (protein)	NP_000304 NP_001301006	NP_035303.1 NP_035303
Location (UCSC)	Chr 3: 93.87 – 93.97 Mb	Chr 16: 62.85 – 62.93 Mb
PubMed search

1Z6C

5627

19128

ENSG00000184500

ENSMUSG00000022912

P07225

Q08761

NM_000313
NM_001314077

NM_011173

NP_000304
NP_001301006

NP_035303.1
NP_035303

Protein S (also known as S-Protein) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein S is encoded by the PROS1 gene.

Protein S is partly homologous to other vitamin K-dependent plasma coagulation proteins, such as protein C and factors VII, IX, and X. Similar to them, it has a Gla domain and several EGF-like domains (four rather than two), but no serine protease domain. Instead, there is a large C-terminus domain that is homologous to plasma steroid hormone-binding proteins such as sex hormone-binding globulin and corticosteroid-binding globulin. It may play a role in the protein functions as either a cofactor for activated protein C (APC) or in binding C4BP.

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