Activated protein C

PROC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AUT, 1LQV, 3F6U, 3JTC, 4DT7
Identifiers
Aliases	PROC, APC, PC, PROC1, THPH3, THPH4, protein C, inactivator of coagulation factors Va and VIIIa
External IDs	OMIM: 612283 MGI: 97771 HomoloGene: 37288 GeneCards: PROC
Gene ontology Molecular function • calcium ion binding • peptidase activity • protein binding • serine-type peptidase activity • serine-type endopeptidase activity • hydrolase activity Cellular component • Golgi apparatus • endoplasmic reticulum lumen • extracellular region • endoplasmic reticulum • Golgi lumen • extracellular space Biological process • hemostasis • negative regulation of coagulation • negative regulation of blood coagulation • blood coagulation • negative regulation of apoptotic process • positive regulation of establishment of endothelial barrier • proteolysis • ER to Golgi vesicle-mediated transport • signal peptide processing • peptidyl-glutamic acid carboxylation • negative regulation of inflammatory response • leukocyte migration • liver development • regulation of circulating fibrinogen levels Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5624	19123
Ensembl	ENSG00000115718	ENSMUSG00000024386
UniProt	P04070	P33587
RefSeq (mRNA)	NM_000312	NM_001042767 NM_001042768 NM_008934 NM_001313938
RefSeq (protein)	NP_000303	NP_001036232.1 NP_001300867.1 NP_001036232 NP_001036233 NP_001300867 NP_032960
Location (UCSC)	Chr 2: 127.42 – 127.43 Mb	Chr 18: 32.12 – 32.14 Mb
PubMed search

1AUT, 1LQV, 3F6U, 3JTC, 4DT7

5624

19123

ENSG00000115718

ENSMUSG00000024386

P04070

P33587

NM_000312

NM_001042767
NM_001042768
NM_008934
NM_001313938

NP_000303

NP_032960

Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, the activated form of which plays an important role in regulating anticoagulation, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals. Activated protein C (APC) performs these operations primarily by proteolytically inactivating proteins Factor V_a and Factor VIII_a. APC is classified as a serine protease as it contains a residue of serine in its active site. In humans, protein C is encoded by the PROC gene, which is found on chromosome 2.

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