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Activated protein C

PROC
Protein PROC PDB 1aut.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PROC, APC, PC, PROC1, THPH3, THPH4, protein C, inactivator of coagulation factors Va and VIIIa
External IDs OMIM: 612283 MGI: 97771 HomoloGene: 37288 GeneCards: PROC
RNA expression pattern
PBB GE PROC 206259 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000312

NM_001042767
NM_001042768
NM_008934
NM_001313938

RefSeq (protein)

NP_000303

Location (UCSC) Chr 2: 127.42 – 127.43 Mb Chr 18: 32.12 – 32.14 Mb
PubMed search

1AUT, 1LQV, 3F6U, 3JTC, 4DT7

NM_000312

NM_001042767
NM_001042768
NM_008934
NM_001313938

NP_000303

NP_032960

Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, the activated form of which plays an important role in regulating anticoagulation, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals. Activated protein C (APC) performs these operations primarily by proteolytically inactivating proteins Factor Va and Factor VIIIa. APC is classified as a serine protease as it contains a residue of serine in its active site. In humans, protein C is encoded by the PROC gene, which is found on chromosome 2.


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Wikipedia

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