Prothrombin complex concentrate
| Combination of | |
|---|---|
| Factor II | Blood clotting factor |
| Factor VII | Blood clotting factor |
| Factor IX | Blood clotting factor |
| Factor X | Blood clotting factor |
| Clinical data | |
| Trade names | Beriplex, Octaplex, Kcentra, others |
| AHFS/Drugs.com | Monograph |
| Routes of administration |
injection |
| ATC code | B02BD01 (WHO) |
| Legal status | |
| Legal status |
|
| Identifiers | |
| Synonyms | factor IX complex |
| CAS Number | 37224-63-8 |
Prothrombin complex concentrate (PCC), also known as factor IX complex, is a medication made up of blood clotting factors II, IX, and X. Some versions also contain factor VII. It is used to treat and prevent bleeding in hemophilia B if pure factor IX is not avaliable. It may also be used in those with not enough of these factors due to other reasons such as warfarin therapy. It is given by slow injection into a vein.
Common side effects include allergic reactions, headache, vomiting, and sleepiness. Other serious side effects include blood clots which may result in a heart attack or pulmonary embolism.Antibodies may form after long term use such that future doses are less effective.
Prothrombin complex concentrate came into medical use in the 1960s. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is made from human plasma. A version that is made by recombinant methods which only contains factor IX is also avaliable. In the United States a dose of PCC costs about 900 USD. A number of different formulations are avaliable globally.
PCC reverses the effects of warfarin and other vitamin K antagonist anti-coagulants and is used in cases of significant bleeding in patients with a coagulopathy (INR > 8.0, prolonged prothrombin time). It is also used when such a patient must undergo an emergency operation treatment. Other indications include a deficiency of one of the included clotting factors, either congenital or due to liver disease, and hemophilia. Several guidelines, including American College of Chest Physicians, recommend PCC for warfarin reversal in patients with serious bleed.
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