5-HT1B receptor

HTR1B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4IAQ, 4IAR

Identifiers

Aliases

HTR1B, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12, 5-HT-1B, 5-HT-1D-beta, 5-hydroxytryptamine receptor 1B

External IDs

MGI: 96274 HomoloGene: 669 GeneCards: HTR1B

Targeted by Drug

frovatriptan, 1-naphthylpiperazine, 2-methyl-5-HT, 5-carboxamidotryptamine, pathogen, 5-methoxytryptamine, 5-(nonyloxy)-tryptamine, (+/-)-8-hydroxy-2-(di-N-propylamino)tetralin, alniditan, aripiprazole, cabergoline, cgs 12066b-parent, clozapine, CP-122288, CP94253, dihydroergotamine, donitriptan, eletriptan, lysergol, olanzapine, oxymetazoline, pergolide, ru-24969, 1-(3-trifluoromethylphenyl)piperazine, tryptamine, xanomeline, ziprasidone, brl-15572, bromocriptine, gr-127935, lisuride, naratriptan, rizatriptan, roxindole, sb-216641, sumatriptan, terguride, vortioxetine, zolmitriptan, ketanserin, metergoline, methysergide, ocaperidone, pipamperone, α-yohimbine, risperidone, ritanserin, sertindole, yohimbine, zotepine, metitepine, SB236057

Gene ontology
Molecular function	• G-protein coupled receptor activity • signal transducer activity • G-protein coupled serotonin receptor activity • protein binding • drug binding • neurotransmitter receptor activity • serotonin binding
Cellular component	• cytoplasm • integral component of membrane • membrane • integral component of plasma membrane • plasma membrane
Biological process	• chemical synaptic transmission • G-protein coupled receptor internalization • G-protein coupled receptor signaling pathway • regulation of dopamine secretion • regulation of behavior • response to mineralocorticoid • behavior • vasoconstriction • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular response to alkaloid • negative regulation of serotonin secretion • cellular response to temperature stimulus • cellular response to drug • negative regulation of synaptic transmission, GABAergic • protein kinase C-activating G-protein coupled receptor signaling pathway • drinking behavior • bone remodeling • feeding behavior • negative regulation of cAMP biosynthetic process • response to ethanol • negative regulation of synaptic transmission, glutamatergic • response to drug • signal transduction • response to cocaine • positive regulation of vascular smooth muscle cell proliferation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3351


15551

Ensembl


ENSG00000135312


ENSMUSG00000049511

UniProt


P28222


P28334

RefSeq (mRNA)


NM_000863


NM_010482

RefSeq (protein)


NP_000854


NP_034612.1 NP_034612

Location (UCSC)

Chr 6: 77.46 – 77.46 Mb

Chr 9: 81.63 – 81.63 Mb

PubMed search

NP_034612.1
NP_034612

5-hydroxytryptamine receptor 1B also known as the 5-HT_1B receptor is a protein that in humans is encoded by the HTR1B gene. The 5-HT_1B receptor is a 5-HT receptor subtype.

5-HT_1B receptors are widely distributed throughout the CNS with the highest concentrations found in the frontal cortex, basal ganglia, striatum, and the hippocampus. The function of the 5-HT_1B receptor differs depending upon its location. In the frontal cortex, it is believed to act as a postsynaptic receptor inhibiting the release of dopamine. In the basal ganglia and the striatum, evidence suggests 5-HT signaling acts on an autoreceptor, inhibiting the release of serotonin and decreasing glutamatergic transmission by reducing miniature excitatory postsynaptic potential (mEPSP) frequency, respectively. In the hippocampus, a recent study has demonstrated that activation of postsynaptic 5-HT_1Bheteroreceptors produces a facilitation in excitatory synaptic transmission which is altered in depression. When the expression of 5-HT_1B in human cortex was traced throughout life, significant changes during adolescence were observed, in a way that is strongly correlated with the expression of 5-HT_1E.

...
Wikipedia