Μ-opioid receptor

OPRM1

Identifiers

Aliases

OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM, opioid receptor mu 1

External IDs

OMIM: 600018 MGI: 97441 HomoloGene: 37368 GeneCards: OPRM1

Genetically Related Diseases

coronary artery disease

Targeted by Drug

cebranopadol, eluxadoline, hydrocodone, hydromorphone, levorphanol, loperamide, methadone, nalbuphine, meperidine, tapentadol, codeine, DADLE, DAMGO, dihydromorphine, endomorphin-1, etonitazene, fentanyl, levomethadone, morphine, sufentanil, buprenorphine, butorphanol, (-)-pentazocine, alvimopan anhydrous, diprenorphine, levallorphan, methylnaltrexone, nalmefene, nalorphine, naloxone, naltrexone, naltriben, naltrindole, quadazocine

Gene ontology
Molecular function	• voltage-gated calcium channel activity • morphine receptor activity • G-protein coupled receptor activity • protein domain specific binding • neuropeptide binding • signal transducer activity • G-protein beta-subunit binding • filamin binding • opioid receptor activity • protein C-terminus binding • protein binding • beta-endorphin receptor activity • G-protein alpha-subunit binding
Cellular component	• postsynapse • cytoplasm • integral component of membrane • perikaryon • Golgi apparatus • membrane • focal adhesion • integral component of plasma membrane • dendrite membrane • endoplasmic reticulum • neuron projection • membrane raft • sarcolemma • dendrite cytoplasm • cell • endosome • plasma membrane • axon • dendrite
Biological process	• positive regulation of appetite • G-protein coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • adenylate cyclase-activating dopamine receptor signaling pathway • sensory perception • negative regulation of cAMP-mediated signaling • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • regulation of sensory perception of pain • eating behavior • locomotory behavior • estrous cycle • positive regulation of cytosolic calcium ion concentration • positive regulation of nitric oxide biosynthetic process • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of Wnt protein secretion • wound healing • acute inflammatory response to antigenic stimulus • positive regulation of cAMP-mediated signaling • positive regulation of neurogenesis • regulation of NMDA receptor activity • phospholipase C-activating G-protein coupled receptor signaling pathway • cellular response to stress • response to morphine • response to lipopolysaccharide • negative regulation of nitric oxide biosynthetic process • calcium ion transmembrane transport • excitatory postsynaptic potential • positive regulation of ERK1 and ERK2 cascade • behavioral response to ethanol • negative regulation of cAMP biosynthetic process • response to food • sensory perception of pain • response to radiation • response to growth factor • response to ethanol • signal transduction • negative regulation of cell proliferation • negative regulation of cytosolic calcium ion concentration • adenylate cyclase-inhibiting opioid receptor signaling pathway • response to cocaine • cellular response to morphine • chemical synaptic transmission • neuropeptide signaling pathway • opioid receptor signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4988


18390

Ensembl


ENSG00000112038


ENSMUSG00000000766

UniProt


P35372


P42866

RefSeq (mRNA)

NM_000914 NM_001008503 NM_001008504 NM_001008505 NM_001145279
NM_001145280 NM_001145281 NM_001145282 NM_001145283 NM_001145284 NM_001145285 NM_001145286 NM_001145287 NM_001285522 NM_001285523 NM_001285524 NM_001285526 NM_001285527 NM_001285528

NM_001039652 NM_011013 NM_001302793 NM_001302794 NM_001302795
NM_001302796 NM_001304937 NM_001304938 NM_001304948 NM_001304950 NM_001304955

RefSeq (protein)

NP_000905 NP_001008503 NP_001008504 NP_001008505 NP_001138751
NP_001138752 NP_001138753 NP_001138754 NP_001138755 NP_001138756 NP_001138757 NP_001138758 NP_001138759 NP_001272451 NP_001272452 NP_001272453 NP_001272455 NP_001272456 NP_001272457

NP_001034741.1 NP_001289722.1 NP_001289723.1 NP_001289724.1 NP_001289725.1
NP_001291866.1 NP_001291867.1 NP_001291877.1 NP_001291879.1 NP_001291884.1 NP_001034741 NP_001289722 NP_001289723 NP_001289724 NP_001289725 NP_001291866 NP_001291867 NP_001291877 NP_001291879 NP_001291884

Location (UCSC)

Chr 6: 154.01 – 154.25 Mb

Chr 10: 6.76 – 7.04 Mb

PubMed search

NM_001145280
NM_001145281
NM_001145282
NM_001145283
NM_001145284
NM_001145285
NM_001145286
NM_001145287
NM_001285522
NM_001285523
NM_001285524
NM_001285526
NM_001285527
NM_001285528

NM_001302796
NM_001304937
NM_001304938
NM_001304948
NM_001304950
NM_001304955

...
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