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Levomethadone

Levomethadone
Levomethadone structure.svg
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral, IV, IM, SC, IT
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability High
Protein binding 60-90%
Biological half-life ~18 hours
Identifiers
CAS Number
PubChem CID
ChemSpider
ECHA InfoCard 100.120.592
Chemical and physical data
Formula C21H27NO
Molar mass 309.445 g/mol
3D model (Jmol)

Levomethadone (INN; L-Polamidon, L-Polamivet, Levadone, Levothyl), or levamethadone, is a synthetic opioid analgesic and antitussive which is marketed in Europe and is used for pain management and in opioid maintenance therapy. In addition to being used as a pharmaceutical drug itself, levomethadone, or R-(−)-methadone, is the active enantiomer of methadone, having approximately 50x the potency of the S-(+)-enantiomer as well as greater μ-opioid receptor selectivity. Accordingly, it is about twice as potent as methadone by weight and its effects are virtually identical in comparison. In addition to its activity at the opioid receptors, levomethadone has been found to act as a weak competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor complex and as a potent noncompetitive antagonist of the α3β4 nicotinic acetylcholine (nACh) receptor.

There is now an asymmetric synthesis available to prepare both levomethadone [R-(−)-methadone] and dextromethadone [S-(+)-methadone].


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