Κ-opioid receptor

OPRK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DJH
Identifiers
Aliases	OPRK1, K-OR-1, KOR, KOR-1, OPRK, opioid receptor kappa 1
External IDs	OMIM: 165196 MGI: 97439 HomoloGene: 20253 GeneCards: OPRK1
Targeted by Drug
cebranopadol, hydrocodone, hydromorphone, meperidine, U50488, enadoline, GR 89696, nalbuphine, nalfurafine, salvinorin A, u-69593, tifluadom, Beta-endorphin, butorphanol, DAMGO, dihydromorphine, etonitazene, fentanyl, levomethadone, morphine, nalorphine, (-)-pentazocine, alvimopan anhydrous, buprenorphine, diprenorphine, methylnaltrexone, nalmefene, naloxone, naltrexone, naltriben, naltrindole, quadazocine, JDTic
Gene ontology Molecular function • G-protein coupled receptor activity • neuropeptide binding • signal transducer activity • opioid receptor activity • protein binding • dynorphin receptor activity Cellular component • axon terminus • integral component of membrane • perikaryon • membrane • plasma membrane • synapse • integral component of plasma membrane • neuronal cell body • dendrite • neuron projection Biological process • positive regulation of p38MAPK cascade • regulation of aerobic respiration • response to cocaine • G-protein coupled receptor signaling pathway • negative regulation of luteinizing hormone secretion • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • sensory perception • behavior • regulation of sensory perception of pain • eating behavior • locomotory behavior • behavioral response to cocaine • sensory perception of temperature stimulus • estrous cycle • conditioned place preference • response to estrogen • response to insulin • phospholipase C-activating G-protein coupled receptor signaling pathway • response to morphine • regulation of saliva secretion • positive regulation of dopamine secretion • opioid receptor signaling pathway • defense response to virus • maternal behavior • immune response • response to acrylamide • positive regulation of potassium ion transmembrane transport • sensory perception of pain • response to radiation • response to ethanol • neuropeptide signaling pathway • cellular response to lipopolysaccharide • positive regulation of locomotion • signal transduction • adenylate cyclase-inhibiting opioid receptor signaling pathway • regulation of energy homeostasis • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4986	18387
Ensembl	ENSG00000082556	ENSMUSG00000025905
UniProt	P41145	P33534
RefSeq (mRNA)	NM_001282904 NM_000912 NM_001318497	NM_001204371 NM_011011 NM_001318735
RefSeq (protein)	NP_000903 NP_001269833 NP_001305426	NP_001191300.1 NP_035141.1 NP_001305664.1 NP_001191300 NP_001305664 NP_035141
Location (UCSC)	Chr 8: 53.23 – 53.25 Mb	Chr 1: 5.59 – 5.61 Mb
PubMed search

4DJH

4986

18387

ENSG00000082556

ENSMUSG00000025905

P41145

P33534

NM_001282904
NM_000912
NM_001318497

NM_001204371
NM_011011
NM_001318735

NP_000903
NP_001269833
NP_001305426

NP_035141

The κ-opioid receptor (KOR) is a protein that in humans is encoded by the OPRK1 gene. The KOR is one of four related receptors that bind opioid-like compounds in the brain and are responsible for mediating the effects of these compounds. These effects include altering nociception, consciousness, motor control, and mood.

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