US Route 421
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| Route information | |
| Auxiliary route of US 21 | |
| Length: | 941 mi (1,514 km) |
| Existed: | 1930 – present |
| Major junctions | |
| South end: | Fort Fisher, North Carolina |
 I‑95 in Dunn, NC    I‑73 / I‑85 / US 70 / US 220 in Greensboro, NC I‑40 in Greensboro and Winston-Salem, NC I‑77 near Yadkinville, NC I‑81 near Bristol, VA I-75 near Lexington, KY I-64 in Midway, KY I-71 near Campbellsburg, KY I-74 in Greensburg, IN and Indianapolis, IN  I-80 / I-90 near Otis, IN I-94 near Michigan City, IN
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| North end: |
 US 20 at Michigan City, Indiana
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| Location | |
| States: | North Carolina, Tennessee, Virginia, Kentucky, Indiana |
| Highway system | |
U.S. Route 421 is a spur route of U.S. 21. It runs for 941 miles (1,514 km) from Michigan City, Indiana, at U.S. 20, to Fort Fisher in North Carolina. The highway goes through the cities of Indianapolis, Indiana, Lexington, Kentucky, Richmond, Kentucky, Boone, North Carolina, Winston-Salem, North Carolina, Greensboro, North Carolina and ends several miles south of Wilmington, North Carolina.
U.S. Route 421 begins at Fort Fisher, North Carolina, and heads generally to the northwest to Michigan City, Indiana. Along the way, it passes through Bristol, Tennessee, and Virginia, Lexington, Kentucky, and Indianapolis, Indiana.
US 421 begins at Fort Fisher and heads through North Carolina's southeastern beaches to Wilmington. It then heads in a northwest direction through Clinton, Dunn, Lillington, Sanford and Siler City to the Piedmont Triad region. Major highway junctures between north of Wilmington and Greensboro are NC 11, I-95, U.S. Route 401, US 1, US 64 and I-85. In Greensboro, it follows the Greensboro Urban Loop paired with Interstate 85 south of Greensboro and I-73 northwest of Greensboro. It then connects to I-40 towards Forsyth County as it becomes its own freeway along the former Interstate 40 alignment known as Business 40. Major intersections are NC 66, US 158 and US 52 between Greensboro and Winston-Salem. After Winston-Salem, it intersects I-40 once again but continues westerly passing through Lewisville, Yadkinville, Wilkesboro and Boone. Major highway junctions between Winston-Salem and Boone are US 601, I-77, NC 16, Blue Ridge Parkway, US 221 and US 321. US 421 continues westerly into Tennessee towards Mountain City, Tennessee. US 421 is a limited access freeway through Siler City northward. US 421 is a divided highway from north of NC 49 all of the way to Wilkesboro.
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Wikipedia