Tumor necrosis factor receptor 2

TNFRSF1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CA9, 3ALQ
Identifiers
Aliases	TNFRSF1B, CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR, tumor necrosis factor receptor superfamily member 1B, TNF receptor superfamily member 1B
External IDs	MGI: 1314883 HomoloGene: 829 GeneCards: TNFRSF1B
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.22 Start 12,167,003 bp End 12,209,228 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 E1|4 78.17 cM Start 145,213,463 bp End 145,246,870 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • ubiquitin protein ligase binding • tumor necrosis factor-activated receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • varicosity • extracellular region • axon • neuronal cell body • perinuclear region of cytoplasm • membrane raft • cell nucleus • specific granule membrane Biological process • extrinsic apoptotic signaling pathway • RNA destabilization • cellular response to growth factor stimulus • positive regulation of membrane protein ectodomain proteolysis • aging • multicellular organism development • cell surface receptor signaling pathway • response to lipopolysaccharide • regulation of cell proliferation • immune response • intrinsic apoptotic signaling pathway in response to DNA damage • apoptotic signaling pathway • inflammatory response • cellular response to lipopolysaccharide • negative regulation of inflammatory response • apoptotic process • tumor necrosis factor-mediated signaling pathway • neutrophil degranulation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cytokine-mediated signaling pathway • aortic valve development • pulmonary valve development • negative regulation of extracellular matrix constituent secretion • negative regulation of cardiac muscle hypertrophy • positive regulation of apoptotic process involved in morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7133	21938
Ensembl	ENSG00000028137	ENSMUSG00000028599
UniProt	P20333	P25119
RefSeq (mRNA)	NM_001066	NM_011610
RefSeq (protein)	NP_001057	NP_035740
Location (UCSC)	Chr 1: 12.17 – 12.21 Mb	Chr 4: 145.21 – 145.25 Mb
PubMed search

1CA9, 3ALQ

7133

21938

ENSG00000028137

ENSMUSG00000028599

P20333

P25119

NM_001066

NM_011610

NP_001057

NP_035740

Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is a membrane receptor that binds tumor necrosis factor-alpha (TNFα).

The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2 (TRAF2), which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

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Wikipedia