TRAF2

TRAF2

Protein TRAF2 PDB 1ca4.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3M0D, 1CA4, 1CA9, 1CZY, 1CZZ, 1D00, 1D01, 1D0A, 1D0J, 1F3V, 1QSC, 3KNV, 3M06, 3M0A

Identifiers

TRAF2, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2

External IDs

OMIM: 601895 MGI: 101835 HomoloGene: 22520 GeneCards: TRAF2

Gene ontology
Molecular function	• sphingolipid binding • lipid binding • CD40 receptor binding • mitogen-activated protein kinase kinase kinase binding • protein complex binding • zinc ion binding • signal transducer activity • metal ion binding • ubiquitin-protein transferase activity • protein binding • identical protein binding • thioesterase binding • enzyme binding • tumor necrosis factor receptor binding • protein phosphatase binding • receptor binding • protein kinase binding • ubiquitin protein ligase binding • transferase activity
Cellular component	• TRAF2-GSTP1 complex • AIP1-IRE1 complex • ubiquitin ligase complex • vesicle membrane • protein complex • cell cortex • membrane raft • CD40 receptor complex • cytoplasmic side of plasma membrane • IRE1-TRAF2-ASK1 complex • nucleoplasm • cytoplasm • cytosol
Biological process	• regulation of apoptotic process • protein heterooligomerization • protein complex assembly • regulation of immunoglobulin secretion • positive regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of JUN kinase activity • negative regulation of glial cell apoptotic process • regulation of tumor necrosis factor-mediated signaling pathway • protein K63-linked ubiquitination • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • positive regulation of sequence-specific DNA binding transcription factor activity • tumor necrosis factor-mediated signaling pathway • activation of NF-kappaB-inducing kinase activity • cellular protein complex assembly • positive regulation of protein homodimerization activity • response to endoplasmic reticulum stress • protein homotrimerization • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • positive regulation of I-kappaB phosphorylation • regulation of JNK cascade • protein catabolic process • positive regulation of T cell activation • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-2 production • death-inducing signaling complex assembly • positive regulation of T cell cytokine production • protein ubiquitination • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of extrinsic apoptotic signaling pathway • cellular response to nitric oxide • regulation of extrinsic apoptotic signaling pathway via death domain receptors • I-kappaB kinase/NF-kappaB signaling • activation of cysteine-type endopeptidase activity involved in apoptotic process • signal transduction • protein autoubiquitination • negative regulation of neuron death • programmed necrotic cell death • apoptotic process • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • protein deubiquitination • regulation of necroptotic process
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE TRAF2 204413 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


7186


22030


ENSG00000127191


ENSMUSG00000026942


Q12933


P39429

RefSeq (mRNA)


NM_021138


NM_009422 NM_001290413

RefSeq (protein)


NP_066961


NP_001277342 NP_033448

Location (UCSC)

Chr 9: 136.88 – 136.93 Mb

Chr 2: 25.52 – 25.55 Mb

PubMed search

3M0D, 1CA4, 1CA9, 1CZY, 1CZZ, 1D00, 1D01, 1D0A, 1D0J, 1F3V, 1QSC, 3KNV, 3M06, 3M0A

ENSG00000127191

ENSMUSG00000026942

NM_009422
NM_001290413

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Wikipedia

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