SOX9

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4EUW

Identifiers

Aliases

SOX9, CMD1, CMPD1, SRA1, SRXX2, SRXY10, SRY-box 9

External IDs

MGI: 98371 HomoloGene: 294 GeneCards: SOX9

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • enhancer binding • core promoter sequence-specific DNA binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • protein kinase activity • protein kinase A catalytic subunit binding • beta-catenin binding • pre-mRNA intronic binding • chromatin binding • protein binding • DNA binding • sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription regulatory region sequence-specific DNA binding • bHLH transcription factor binding • enhancer sequence-specific DNA binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Cellular component	• nucleus • transcription factor complex • nucleoplasm • protein complex • nuclear transcription factor complex
Biological process	• skeletal system development • cellular response to retinoic acid • bronchus cartilage development • positive regulation of protein phosphorylation • heart valve development • limb bud formation • positive regulation of protein catabolic process • regulation of transcription from RNA polymerase II promoter • ureter morphogenesis • negative regulation of immune system process • chondrocyte development • positive regulation of cell proliferation involved in heart morphogenesis • oligodendrocyte differentiation • chondrocyte hypertrophy • prostate gland development • lung smooth muscle development • mammary gland development • negative regulation of ossification • negative regulation of photoreceptor cell differentiation • cellular response to mechanical stimulus • intrahepatic bile duct development • regulation of cell adhesion • negative regulation of chondrocyte differentiation • positive regulation of mesenchymal cell proliferation • astrocyte fate commitment • positive regulation of chondrocyte differentiation • spermatogenesis • prostate gland morphogenesis • negative regulation of epithelial cell proliferation • lung epithelial cell differentiation • chondrocyte differentiation involved in endochondral bone morphogenesis • negative regulation of canonical Wnt signaling pathway • endocrine pancreas development • negative regulation of cell proliferation • regulation of apoptotic process • cellular response to transforming growth factor beta stimulus • negative regulation of mesenchymal cell apoptotic process • chromatin remodeling • negative regulation of myoblast differentiation • positive regulation of branching involved in ureteric bud morphogenesis • cell fate commitment • regulation of transcription, DNA-templated • epidermal growth factor receptor signaling pathway • ossification • regulation of cell proliferation involved in tissue homeostasis • ureter smooth muscle cell differentiation • ERK1 and ERK2 cascade • notochord development • positive regulation of epithelial cell migration • Sertoli cell differentiation • male sex determination • negative regulation of gene expression • transcription, DNA-templated • metanephric nephron tubule formation • positive regulation of transcription, DNA-templated • heart development • regulation of branching involved in lung morphogenesis • ureter urothelium development • branching involved in ureteric bud morphogenesis • cartilage development • Harderian gland development • positive regulation of kidney development • central nervous system development • heart valve formation • positive regulation of cartilage development • tissue homeostasis • metanephric tubule development • negative regulation of biomineral tissue development • endochondral bone morphogenesis • trachea cartilage development • male germ-line sex determination • lacrimal gland development • Notch signaling pathway • hair follicle development • single organismal cell-cell adhesion • cell differentiation • ureter development • regulation of cell cycle process • male gonad development • chondrocyte differentiation • positive regulation of epithelial cell proliferation • cell fate specification • intestinal epithelial structure maintenance • positive regulation of extracellular matrix assembly • extracellular matrix organization • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • Sertoli cell development • positive regulation of mesenchymal stem cell differentiation • retina development in camera-type eye • cellular response to interleukin-1 • epithelial to mesenchymal transition • homeostasis of number of cells within a tissue • negative regulation of transcription, DNA-templated • cAMP-mediated signaling • cartilage condensation • positive regulation of male gonad development • nucleosome assembly • negative regulation of bone mineralization • morphogenesis of a branching epithelium • neural crest cell development • protein kinase B signaling • somatic stem cell population maintenance • protein complex assembly • otic vesicle formation • otic vesicle development • endocardial cushion morphogenesis • cellular response to epidermal growth factor stimulus • positive regulation of epithelial cell differentiation • renal vesicle induction • positive regulation of gene expression • regulation of epithelial cell proliferation involved in lung morphogenesis • regulation of cell proliferation • heart valve morphogenesis • cytoskeleton organization • cochlea morphogenesis • positive regulation of cell proliferation • epithelial cell proliferation involved in prostatic bud elongation • retinal rod cell differentiation • protein localization to nucleus • regulation of cell differentiation • positive regulation of phosphatidylinositol 3-kinase signaling • cellular response to heparin • negative regulation of epithelial cell differentiation • epithelial tube branching involved in lung morphogenesis • signal transduction • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • negative regulation of pri-miRNA transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6662


20682

Ensembl


ENSG00000125398


ENSMUSG00000000567

UniProt


P48436


Q04887

RefSeq (mRNA)


NM_000346


NM_011448

RefSeq (protein)


NP_000337


NP_035578.3 NP_035578

Location (UCSC)

Chr 17: 72.12 – 72.13 Mb

Chr 11: 112.78 – 112.79 Mb

PubMed search

NP_035578.3
NP_035578

Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.

SOX-9 recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Müllerian hormone (AMH) gene.

SOX-9 also plays a pivotal role in male sexual development; by working with Sf1, SOX-9 can produce AMH in Sertoli cells to inhibit the creation of a female reproductive system. It also interacts with a few other genes to promote the development of male sexual organs. The process starts when the transcription factor Testis determining factor (encoded by the sex-determining region SRY of the Y chromosome) activates SOX-9 activity by binding to an enhancer sequence upstream of the gene. Next, Sox9 activates FGF9 and forms feedforward loops with FGF9 and PGD2. These loops are important for producing SOX-9; without these loops, SOX-9 would run out and the development of a female would almost certainly ensue. Activation of FGF9 by SOX-9 starts vital processes in male development, such as the creation of testis cords and the multiplication of Sertoli cells. The association of SOX-9 and Dax1 actually creates Sertoli cells, another vital process in male development.

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Wikipedia