FGF9

FGF9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G82, 1IHK
Identifiers
Aliases	FGF9, FGF-9, GAF, HBFG-9, HBGF-9, SYNS3, fibroblast growth factor 9
External IDs	MGI: 104723 HomoloGene: 1523 GeneCards: FGF9
Gene ontology Molecular function • heparin binding • fibroblast growth factor receptor binding • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • growth factor activity • Ras guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • extracellular region • basement membrane • extracellular exosome • extracellular space Biological process • eye development • positive regulation of vascular endothelial growth factor receptor signaling pathway • cell differentiation • male gonad development • chondrocyte differentiation • substantia nigra development • protein import into nucleus • positive regulation of smoothened signaling pathway • regulation of timing of cell differentiation • positive regulation of epithelial cell proliferation • lung development • positive regulation of canonical Wnt signaling pathway • negative regulation of Wnt signaling pathway • negative regulation of transcription from RNA polymerase II promoter • male sex determination • MAPK cascade • embryonic skeletal system development • multicellular organism development • positive regulation of gene expression • positive regulation of activin receptor signaling pathway • positive regulation of cardiac muscle cell proliferation • positive regulation of mesenchymal cell proliferation • embryonic limb morphogenesis • inner ear morphogenesis • angiogenesis • osteoblast differentiation • positive regulation of cell proliferation • lung-associated mesenchyme development • embryonic digestive tract development • positive regulation of cell division • phosphatidylinositol-mediated signaling • signal transduction • positive regulation of MAPK cascade • phosphatidylinositol phosphorylation • fibroblast growth factor receptor signaling pathway • cell-cell signaling • phosphatidylinositol-3-phosphate biosynthetic process • positive regulation of GTPase activity • regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2254	14180
Ensembl	ENSG00000102678	ENSMUSG00000021974
UniProt	P31371	P54130
RefSeq (mRNA)	NM_002010	NM_013518
RefSeq (protein)	NP_002001	NP_038546
Location (UCSC)	Chr 13: 21.67 – 21.7 Mb	Chr 14: 58.07 – 58.11 Mb
PubMed search

1G82, 1IHK

2254

14180

ENSG00000102678

ENSMUSG00000021974

P31371

P54130

NM_002010

NM_013518

NP_002001

NP_038546

Glia-activating factor is a protein that in humans is encoded by the FGF9 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. This gene is involved in the patterning of sex determination, lung development, and skeletal development.

...
Wikipedia