Sonic hedgehog

SHH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HO5, 3M1N, 3MXW
Identifiers
Aliases	SHH, HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS, sonic hedgehog, Sonic hedgehog
External IDs	OMIM: 600725 MGI: 98297 HomoloGene: 30961 GeneCards: SHH
Gene ontology Molecular function • calcium ion binding • glycoprotein binding • metal ion binding • patched binding • peptidase activity • zinc ion binding • laminin-1 binding • protein binding • glycosaminoglycan binding • morphogen activity • hydrolase activity Cellular component • cytosol • endoplasmic reticulum lumen • membrane • extracellular region • cell surface • membrane raft • proteinaceous extracellular matrix • plasma membrane • extracellular space Biological process • positive regulation of skeletal muscle cell proliferation • pattern specification process • myotube differentiation • mesenchymal cell proliferation • male genitalia development • bud outgrowth involved in lung branching • limb bud formation • T cell differentiation in thymus • embryonic pattern specification • positive regulation of skeletal muscle tissue development • embryo development • positive regulation of immature T cell proliferation in thymus • positive regulation of kidney smooth muscle cell differentiation • negative regulation of Wnt signaling pathway • anatomical structure formation involved in morphogenesis • ectoderm development • hindgut morphogenesis • spinal cord dorsal/ventral patterning • formation of anatomical boundary • oligodendrocyte differentiation • trachea development • prostate gland development • negative regulation of transcription elongation from RNA polymerase II promoter • limb development • vasculogenesis • primary prostatic bud elongation • heart looping • telencephalon regionalization • odontogenesis of dentin-containing tooth • positive regulation of mesenchymal cell proliferation • angiogenesis • positive regulation of epithelial cell proliferation involved in prostate gland development • positive regulation of striated muscle cell differentiation • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • embryonic digestive tract morphogenesis • apoptotic signaling pathway • inner ear development • hair follicle morphogenesis • cell proliferation • metanephros development • lung epithelium development • negative regulation of canonical Wnt signaling pathway • regulation of proteolysis • branching involved in salivary gland morphogenesis • negative regulation of mesenchymal cell apoptotic process • positive regulation of neuroblast proliferation • dopaminergic neuron differentiation • intermediate filament organization • renal system development • cell fate commitment • regulation of transcription, DNA-templated • positive regulation of smoothened signaling pathway • androgen metabolic process • kidney development • lung development • negative regulation of protein catabolic process • thymus development • embryonic organ development • negative regulation of cell differentiation • negative regulation of dopaminergic neuron differentiation • embryonic digit morphogenesis • negative regulation of alpha-beta T cell differentiation • positive regulation of sclerotome development • epithelial-mesenchymal cell signaling • negative regulation of gene expression • lymphoid progenitor cell differentiation • negative thymic T cell selection • positive regulation of transcription, DNA-templated • positive regulation of Wnt signaling pathway • ventral midline development • central nervous system development • heart development • branching involved in ureteric bud morphogenesis • negative regulation of T cell proliferation • embryonic limb morphogenesis • positive regulation of cell differentiation • branching involved in prostate gland morphogenesis • positive regulation of mesenchymal cell proliferation involved in ureter development • establishment of cell polarity • branching involved in blood vessel morphogenesis • positive regulation of cerebellar granule cell precursor proliferation • neuroblast proliferation • pancreas development • positive regulation of protein import into nucleus • smoothened signaling pathway • oligodendrocyte development • camera-type eye development • spinal cord motor neuron differentiation • positive regulation of alpha-beta T cell differentiation • digestive tract morphogenesis • hair follicle development • positive regulation of oligodendrocyte differentiation • palate development • left lung development • striated muscle tissue development • positive regulation of T cell differentiation in thymus • cellular response to lithium ion • embryonic foregut morphogenesis • anatomical structure development • thalamus development • stem cell development • smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation • cell fate specification • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry • proteolysis • embryonic skeletal system development • regulation of protein localization to nucleus • odontogenesis • respiratory tube development • regulation of prostatic bud formation • thyroid gland development • negative regulation of cell migration • developmental growth • right lung development • determination of left/right asymmetry in lateral mesoderm • positive thymic T cell selection • mesenchymal smoothened signaling pathway involved in prostate gland development • canonical Wnt signaling pathway • regulation of gene expression • osteoblast development • negative regulation of cholesterol efflux • dorsal/ventral neural tube patterning • regulation of epithelial cell proliferation involved in prostate gland development • epithelial-mesenchymal signaling involved in prostate gland development • dorsal/ventral pattern formation • branching morphogenesis of an epithelial tube • lung lobe morphogenesis • embryonic forelimb morphogenesis • midbrain development • skin development • regulation of odontogenesis • regulation of mesenchymal cell proliferation involved in prostate gland development • mesenchymal cell proliferation involved in lung development • positive regulation of hh target transcription factor activity • prostate epithelial cord elongation • metanephric mesenchymal cell proliferation involved in metanephros development • endocytosis • lung morphogenesis • cell development • trachea morphogenesis • epithelial cell proliferation involved in salivary gland morphogenesis • cell-cell signaling • salivary gland cavitation • hindbrain development • blood coagulation • negative regulation of kidney smooth muscle cell differentiation • somite development • cerebellar granule cell precursor proliferation • axon guidance • negative regulation of ureter smooth muscle cell differentiation • positive regulation of ureter smooth muscle cell differentiation • multicellular organism development • animal organ formation • intein-mediated protein splicing • determination of left/right symmetry • vasculature development • positive regulation of gene expression • regulation of cell proliferation • embryonic morphogenesis • neural crest cell migration • polarity specification of anterior/posterior axis • positive regulation of cell proliferation • artery development • protein localization to nucleus • Bergmann glial cell differentiation • forebrain development • neuron fate commitment • CD4-positive or CD8-positive, alpha-beta T cell lineage commitment • striated muscle cell differentiation • myoblast differentiation • lung-associated mesenchyme development • epithelial tube branching involved in lung morphogenesis • positive regulation of cell division • positive regulation of transcription from RNA polymerase II promoter • anterior/posterior pattern specification • embryonic hindlimb morphogenesis • forebrain regionalization • cell proliferation in external granule layer • tracheoesophageal septum formation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6469	20423
Ensembl	ENSG00000164690	ENSMUSG00000002633
UniProt	Q15465	Q62226
RefSeq (mRNA)	NM_000193 NM_001310462	NM_009170
RefSeq (protein)	NP_000184 NP_001297391	NP_033196.1 NP_033196
Location (UCSC)	Chr 7: 155.8 – 155.81 Mb	Chr 5: 28.46 – 28.47 Mb
PubMed search

3HO5, 3M1N, 3MXW

6469

20423

ENSG00000164690

ENSMUSG00000002633

Q15465

Q62226

NM_000193
NM_001310462

NM_009170

NP_000184
NP_001297391

NP_033196.1
NP_033196

Sonic hedgehog is a protein that in humans is encoded by the SHH ("sonic hedgehog") gene. Both the gene and the protein may also be found notated alternatively as "Shh".

Sonic hedgehog is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and Indian hedgehog (IHH). SHH is the best studied ligand of the hedgehog signaling pathway. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. Sonic hedgehog is the best established example of a morphogen as defined by Lewis Wolpert's French flag model—a molecule that diffuses to form a concentration gradient and has different effects on the cells of the developing embryo depending on its concentration. SHH remains important in the adult. It controls cell division of adult stem cells and has been implicated in the development of some cancers.

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