Indian Hedgehog (protein)

IHH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3K7G, 3K7H, 3K7I, 3K7J, 3N1F, 3N1M, 3N1O, 3N1P
Identifiers
Aliases	IHH, BDA1, HHG2, indian hedgehog
External IDs	MGI: 96533 HomoloGene: 22586 GeneCards: IHH
Gene location (Human) Chr. Chromosome 2 (human) Band n/a Start 219,054,420 bp End 219,060,467 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band n/a Start 74,945,315 bp End 74,951,672 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • metal ion binding • peptidase activity • hydrolase activity • patched binding Cellular component • membrane • plasma • extracellular region • extracellular space • proteinaceous extracellular matrix Biological process • response to estradiol • maternal process involved in female pregnancy • positive regulation of epithelial cell proliferation • cell-cell signaling • negative regulation of apoptotic process • proteolysis • multicellular organism development • intein-mediated protein splicing • smoothened signaling pathway • positive regulation of transcription from RNA polymerase II promoter • skeletal system development • ossification • branching involved in blood vessel morphogenesis • osteoblast differentiation • in utero embryonic development • cell fate specification • morphogenesis of a branching structure • vasculature development • heart looping • positive regulation of mesenchymal cell proliferation • epithelial cell morphogenesis • retinal pigment epithelium development • chondrocyte differentiation involved in endochondral bone morphogenesis • proteoglycan metabolic process • pattern specification process • positive regulation of cell proliferation • embryonic pattern specification • cell differentiation • vitelline membrane formation • pancreas development • positive regulation of collagen biosynthetic process • negative regulation of T cell differentiation in thymus • negative regulation of immature T cell proliferation in thymus • positive regulation of T cell differentiation in thymus • multicellular organism growth • chondrocyte proliferation • regulation of growth • embryonic digit morphogenesis • camera-type eye development • bone resorption • negative regulation of cell differentiation • positive regulation of smoothened signaling pathway • positive regulation of alpha-beta T cell differentiation • negative regulation of alpha-beta T cell differentiation • negative regulation of eye pigmentation • cell maturation • embryonic digestive tract morphogenesis • embryonic camera-type eye morphogenesis • neuron development • smooth muscle tissue development • cartilage development • camera-type eye photoreceptor cell fate commitment • head morphogenesis • somite development • embryonic skeletal joint development • epithelial cell-cell adhesion • response to mechanical stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3549	16147
Ensembl	ENSG00000163501	ENSMUSG00000006538
UniProt	Q14623	P97812
RefSeq (mRNA)	NM_002181	NM_010544 NM_001313683
RefSeq (protein)	NP_002172	NP_001300612 NP_034674
Location (UCSC)	Chr 2: 219.05 – 219.06 Mb	Chr 2: 74.95 – 74.95 Mb
PubMed search

3K7G, 3K7H, 3K7I, 3K7J, 3N1F, 3N1M, 3N1O, 3N1P

3549

16147

ENSG00000163501

ENSMUSG00000006538

Q14623

P97812

NM_002181

NM_010544
NM_001313683

NP_002172

NP_001300612
NP_034674

Indian hedgehog homolog (Drosophila), also known as IHH, is a protein which in humans is encoded by the IHH gene. This cell signaling protein is in the hedgehog signaling pathway. The several mammalian variants of the Drosophila hedgehog gene (which was the first named) have been named after the various species of hedgehog; the Indian hedgehog is honored by this one. The gene is not specific to Indian hedgehogs.

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