DHH (hedgehog)

DHH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WFQ, 2WFR, 2WG3, 3N1G, 3N1Q
Identifiers
Aliases	DHH, GDXYM, HHG-3, SRXY7, C78960, desert hedgehog
External IDs	MGI: 94891 HomoloGene: 22431 GeneCards: DHH
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.12 Start 49,089,421 bp End 49,094,819 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 F1|15 55.05 cM Start 98,893,031 bp End 98,898,540 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • zinc ion binding • metal ion binding • patched binding • peptidase activity • protein binding • hydrolase activity Cellular component • membrane • plasma membrane • extracellular region • extracellular space Biological process • response to estradiol • Leydig cell differentiation • cell-cell signaling • regulation of steroid biosynthetic process • male sex determination • proteolysis • response to estrogen • multicellular organism development • spermatid development • myelination • osteoblast differentiation • smoothened signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50846	13363
Ensembl	ENSG00000139549	ENSMUSG00000023000
UniProt	O43323	Q61488
RefSeq (mRNA)	NM_021044	NM_007857
RefSeq (protein)	NP_066382	NP_031883
Location (UCSC)	Chr 12: 49.09 – 49.09 Mb	Chr 15: 98.89 – 98.9 Mb
PubMed search

desert hedgehog
Identifiers
Symbol	DHH
Alt. symbols	HHG-3, MGC35145
Entrez	50846
HUGO	2865
OMIM	605423
RefSeq	NM_021044
UniProt	O43323
Other data
Locus	Chr. 12 q13.1

2WFQ, 2WFR, 2WG3, 3N1G, 3N1Q

50846

13363

ENSG00000139549

ENSMUSG00000023000

O43323

Q61488

NM_021044

NM_007857

NP_066382

NP_031883

Desert hedgehog, also Desert hedgehog homolog or Dhh, is a protein encoded by the DHH gene, and is a member of the hedgehog signaling pathway. The human homolog (DHH) is on chromosome band 12q13.1. The protein encoded by this gene is involved in cell signaling. The several mammalian variants of the Drosophila hedgehog gene (which was the first named) have been named after the various species of hedgehog; the desert hedgehog is honored by this one. The gene is not specific to desert hedgehogs.

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