Steroidogenic factor 1

NR5A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YOW, 1ZDT, 4QJR, 4QK4
Identifiers
Aliases	NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3, hSF-1, nuclear receptor subfamily 5 group A member 1
External IDs	OMIM: 184757 MGI: 1346833 HomoloGene: 3638 GeneCards: NR5A1
Gene ontology Molecular function • protein binding • zinc ion binding • lipid binding • double-stranded DNA binding • enzyme binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • steroid hormone receptor activity • transcription coactivator activity • phospholipid binding • sequence-specific DNA binding • metal ion binding • transcription factor activity, sequence-specific DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • chromatin binding • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding Cellular component • nucleoplasm • RNA polymerase II transcription factor complex • nucleus Biological process • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • regulation of steroid biosynthetic process • hormone metabolic process • luteinization • reproductive process • hormone-mediated signaling pathway • primary sex determination • tissue development • multicellular organism aging • cell differentiation • maintenance of protein location in nucleus • regulation of transcription, DNA-templated • adrenal gland development • transcription, DNA-templated • female gonad development • steroid hormone mediated signaling pathway • cell-cell signaling • transcription from RNA polymerase II promoter • negative regulation of female gonad development • transcription initiation from RNA polymerase II promoter • male gonad development • positive regulation of male gonad development • intracellular receptor signaling pathway • positive regulation of gene expression • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2516	26423
Ensembl	ENSG00000136931	ENSMUSG00000026751
UniProt	Q13285	P33242
RefSeq (mRNA)	NM_004959	NM_139051 NM_001316687
RefSeq (protein)	NP_004950 NP_004950.2	NP_620639.1 NP_001303616.1 NP_001303616 NP_620639
Location (UCSC)	Chr 9: 124.48 – 124.51 Mb	Chr 2: 38.69 – 38.71 Mb
PubMed search

1YOW, 1ZDT, 4QJR, 4QK4

2516

26423

ENSG00000136931

ENSMUSG00000026751

Q13285

P33242

NM_004959

NM_139051
NM_001316687

NP_004950
NP_004950.2

NP_620639.1
NP_001303616.1
NP_001303616
NP_620639

The steroidogenic factor 1 (SF1) protein controls sexual development in the embryo and at puberty.

SF1 is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the NR5A1 gene (nuclear receptor subfamily 5, group A, member 1).

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