Retinoid X receptor

retinoid X receptor alpha
Identifiers
Symbol	RXRA
Entrez	6256
HUGO	10477
OMIM	180245
RefSeq	NM_002957
UniProt	P19793
Other data
Locus	Chr. 9 q34

retinoid X receptor beta
Identifiers
Symbol	RXRB
Entrez	6257
HUGO	10478
OMIM	180246
RefSeq	NM_021976
UniProt	P28702
Other data
Locus	Chr. 6 p21.3

retinoid X receptor gamma
Identifiers
Symbol	RXRG
Entrez	6258
HUGO	10479
OMIM	180247
RefSeq	NM_006917
UniProt	P48443
Other data
Locus	Chr. 1 q22-q23

The retinoid X receptor (RXR) is a type of nuclear receptor that is activated by 9-cis retinoic acid, which is discussed controversially to be of endogenous relevance, and 9-cis-13,14-dihydro-retinoic acid, which is likely to be the major endogenous mammalian RXR-selective agonist. There are three retinoic X receptors (RXR): RXR-alpha, RXR-beta, and RXR-gamma, encoded by the RXRA, RXRB, RXRG genes, respectively.

RXR heterodimerizes with subfamily 1 nuclear receptors including CAR, FXR, LXR, PPAR,PXR, RAR, TR, and VDR.

As with other type II nuclear receptors, the RXR heterodimer in the absence of ligand is bound to hormone response elements complexed with corepressor protein. Binding of agonist ligands to RXR results in dissociation of corepressor and recruitment of coactivator protein, which, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.

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Wikipedia