Retinoid X receptor gamma

RXRG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GL8
Identifiers
Aliases	RXRG, NR2B3, RXRC, Retinoid X receptor gamma
External IDs	MGI: 98216 HomoloGene: 21373 GeneCards: RXRG
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.3 Start 165,400,917 bp End 165,445,355 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H2.3|1 74.99 cM Start 167,598,384 bp End 167,639,623 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • zinc ion binding • RNA polymerase II regulatory region sequence-specific DNA binding • DNA binding • metal ion binding • sequence-specific DNA binding • steroid hormone receptor activity • protein binding • 9-cis retinoic acid receptor activity Cellular component • nucleus • nucleoplasm Biological process • retinoic acid receptor signaling pathway • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • protein homotetramerization • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • transcription, DNA-templated • steroid hormone mediated signaling pathway • transcription initiation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6258	20183
Ensembl	ENSG00000143171	ENSMUSG00000015843
UniProt	P48443	P28705
RefSeq (mRNA)	NM_001256570 NM_001256571 NM_006917	NM_001159731 NM_009107
RefSeq (protein)	NP_001243499 NP_001243500 NP_008848	NP_001153203 NP_033133
Location (UCSC)	Chr 1: 165.4 – 165.45 Mb	Chr 1: 167.6 – 167.64 Mb
PubMed search

2GL8

6258

20183

ENSG00000143171

ENSMUSG00000015843

P48443

P28705

NM_001256570
NM_001256571
NM_006917

NM_001159731
NM_009107

NP_001243499
NP_001243500
NP_008848

NP_001153203
NP_033133

Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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