Calcitriol receptor

VDR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DB1, 1IE8, 1IE9, 1KB2, 1KB4, 1KB6, 1S0Z, 1S19, 1TXI, 1YNW, 2HAM, 2HAR, 2HAS, 2HB7, 2HB8, 3A2I, 3A2J, 3A3Z, 3A40, 3A78, 3AUQ, 3AUR, 3AX8, 3AZ1, 3AZ2, 3AZ3, 3B0T, 3CS4, 3CS6, 3KPZ, 3M7R, 3OGT, 3P8X, 3TKC, 3VHW, 4G2I, 3W0A, 3W0C, 3W0Y, 3WGP, 3WWR, 4ITE, 4ITF, 4PA2, 3X31, 3X36
Identifiers
Aliases	VDR, NR1I1, PPP1R163, vitamin D (1,25- dihydroxyvitamin D3) receptor
External IDs	OMIM: 601769 MGI: 103076 HomoloGene: 37297 GeneCards: VDR
Targeted by Drug
calcitriol, calcipotriene, doxercalciferol, lithocholic acid, paricalcitol, tacalcitol
Gene ontology Molecular function • retinoid X receptor binding • lithocholic acid binding • sequence-specific DNA binding • calcitriol receptor activity • calcitriol binding • DNA binding • lithocholic acid receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • steroid hormone receptor activity • protein binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • metal ion binding • vitamin D response element binding Cellular component • nucleus • nucleoplasm • receptor complex • RNA polymerase II transcription factor complex Biological process • negative regulation of cell proliferation • positive regulation of apoptotic process involved in mammary gland involution • positive regulation of keratinocyte differentiation • regulation of calcidiol 1-monooxygenase activity • intestinal absorption • calcium ion transport • steroid hormone mediated signaling pathway • regulation of transcription, DNA-templated • lactation • bile acid signaling pathway • animal organ morphogenesis • cell morphogenesis • skeletal system development • positive regulation of gene expression • positive regulation of transcription from RNA polymerase II promoter • multicellular organism development • negative regulation of keratinocyte proliferation • decidualization • vitamin D receptor signaling pathway • negative regulation of transcription from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • positive regulation of vitamin D 24-hydroxylase activity • mammary gland branching involved in pregnancy • signal transduction • cellular calcium ion homeostasis • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7421	22337
Ensembl	ENSG00000111424	ENSMUSG00000022479
UniProt	P11473	P48281
RefSeq (mRNA)	NM_000376 NM_001017535 NM_001017536	NM_009504
RefSeq (protein)	NP_000367 NP_001017535 NP_001017536	NP_033530.2 NP_033530
Location (UCSC)	Chr 12: 47.84 – 47.94 Mb	Chr 15: 97.85 – 97.91 Mb
PubMed search

1DB1, 1IE8, 1IE9, 1KB2, 1KB4, 1KB6, 1S0Z, 1S19, 1TXI, 1YNW, 2HAM, 2HAR, 2HAS, 2HB7, 2HB8, 3A2I, 3A2J, 3A3Z, 3A40, 3A78, 3AUQ, 3AUR, 3AX8, 3AZ1, 3AZ2, 3AZ3, 3B0T, 3CS4, 3CS6, 3KPZ, 3M7R, 3OGT, 3P8X, 3TKC, 3VHW, 4G2I, 3W0A, 3W0C, 3W0Y, 3WGP, 3WWR, 4ITE, 4ITF, 4PA2, 3X31, 3X36

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