Retinoid X receptor alpha

RXRA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BY4, 1DSZ, 1FBY, 1FM6, 1FM9, 1G1U, 1G5Y, 1K74, 1LBD, 1MV9, 1MVC, 1MZN, 1R0N, 1RDT, 1RXR, 1XLS, 1XV9, 1XVP, 1YNW, 2ACL, 2NLL, 2P1T, 2P1U, 2P1V, 2ZXZ, 2ZY0, 3DZU, 3DZY, 3E00, 3E94, 3FAL, 3FC6, 3FUG, 3H0A, 3KWY, 3NSP, 3NSQ, 3OAP, 3OZJ, 3PCU, 3R29, 3R2A, 3R5M, 3UVV, 4CN2, 4CN3, 4CN5, 4CN7, 4J5W, 4J5X, 4K4J, 4K6I, 4M8E, 4M8H, 4N5G, 4N8R, 4NQA, 4OC7, 4POH, 4POJ, 4PP3, 4PP5, 4RFW, 4RMC, 4RMD, 4RME, 4ZO1, 5EC9, 4ZSH
Identifiers
Aliases	RXRA, NR2B1, Retinoid X receptor alpha
External IDs	MGI: 98214 HomoloGene: 2220 GeneCards: RXRA
Targeted by Drug
alitretinoin, bexarotene
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • vitamin D response element binding • transcription coactivator activity • transcription factor binding • retinoic acid-responsive element binding • zinc ion binding • metal ion binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • protein binding • protein heterodimerization activity • enzyme binding • transcription regulatory region DNA binding • chromatin DNA binding • retinoic acid receptor activity • vitamin D receptor binding • 9-cis retinoic acid receptor activity Cellular component • receptor complex • nucleoplasm • RNA polymerase II transcription factor complex • nuclear chromatin • nucleus Biological process • steroid hormone mediated signaling pathway • regulation of branching involved in prostate gland morphogenesis • regulation of transcription, DNA-templated • cellular lipid metabolic process • placenta development • peroxisome proliferator activated receptor signaling pathway • regulation of transcription from RNA polymerase II promoter • cholesterol metabolic process • in utero embryonic development • negative regulation of transcription from RNA polymerase II promoter • cardiac muscle cell proliferation • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development • transcription, DNA-templated • positive regulation of transcription, DNA-templated • ventricular cardiac muscle tissue morphogenesis • heart development • retinoic acid receptor signaling pathway • maternal placenta development • modulation by virus of host morphology or physiology • vitamin metabolic process • bile acid and bile salt transport • ventricular cardiac muscle cell differentiation • camera-type eye development • viral process • protein homotetramerization • transcription initiation from RNA polymerase II promoter • embryo implantation • positive regulation of translational initiation by iron • positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • response to retinoic acid Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6256	20181
Ensembl	ENSG00000186350	ENSMUSG00000015846
UniProt	P19793	P28700
RefSeq (mRNA)	NM_002957 NM_001291920 NM_001291921	NM_001290481 NM_001290482 NM_011305
RefSeq (protein)	NP_001278849 NP_001278850 NP_002948	NP_035435.1 NP_001277410 NP_001277411 NP_035435
Location (UCSC)	Chr 9: 134.32 – 134.44 Mb	Chr 2: 27.68 – 27.76 Mb
PubMed search

1BY4, 1DSZ, 1FBY, 1FM6, 1FM9, 1G1U, 1G5Y, 1K74, 1LBD, 1MV9, 1MVC, 1MZN, 1R0N, 1RDT, 1RXR, 1XLS, 1XV9, 1XVP, 1YNW, 2ACL, 2NLL, 2P1T, 2P1U, 2P1V, 2ZXZ, 2ZY0, 3DZU, 3DZY, 3E00, 3E94, 3FAL, 3FC6, 3FUG, 3H0A, 3KWY, 3NSP, 3NSQ, 3OAP, 3OZJ, 3PCU, 3R29, 3R2A, 3R5M, 3UVV, 4CN2, 4CN3, 4CN5, 4CN7, 4J5W, 4J5X, 4K4J, 4K6I, 4M8E, 4M8H, 4N5G, 4N8R, 4NQA, 4OC7, 4POH, 4POJ, 4PP3, 4PP5, 4RFW, 4RMC, 4RMD, 4RME, 4ZO1, 5EC9, 4ZSH

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