Farnesoid X receptor

NR1H4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OSH, 3BEJ, 3DCT, 3DCU, 3FLI, 3FXV, 3GD2, 3HC5, 3HC6, 3L1B, 3OKH, 3OKI, 3OLF, 3OMK, 3OMM, 3OOF, 3OOK, 3RUT, 3RUU, 3RVF, 3P88, 3P89, 4OIV, 4WVD, 4QE6, 4QE8
Identifiers
Aliases	NR1H4, BAR, FXR, HRR-1, HRR1, RIP14, nuclear receptor subfamily 1 group H member 4
External IDs	OMIM: 603826 MGI: 1352464 HomoloGene: 3760 GeneCards: NR1H4
Targeted by Drug
chenodiol, fexaramine, obeticholic acid, (E)-guggulsterone
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • sequence-specific DNA binding • DNA binding • transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • metal ion binding • retinoid X receptor binding • steroid hormone receptor activity • transcriptional activator activity, RNA polymerase II transcription factor binding • thyroid hormone receptor activity • bile acid binding • protein binding • ligand-dependent nuclear receptor binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • chenodeoxycholic acid binding • transcription regulatory region sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • bile acid receptor activity Cellular component • nuclear euchromatin • nucleoplasm • nucleus Biological process • Notch signaling pathway • cellular triglyceride homeostasis • cellular response to organonitrogen compound • regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of ammonia assimilation cycle • toll-like receptor 4 signaling pathway • immune system process • histone H3-R17 methylation • regulation of transcription from RNA polymerase II promoter • negative regulation of interferon-gamma secretion • positive regulation of glutamate metabolic process • intracellular bile acid receptor signaling pathway • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of low-density lipoprotein particle clearance • regulation of bile acid biosynthetic process • regulation of cholesterol metabolic process • regulation of urea metabolic process • intracellular receptor signaling pathway • negative regulation of bile acid biosynthetic process • cellular response to fatty acid • bile acid and bile salt transport • nitrogen catabolite activation of transcription from RNA polymerase II promoter • negative regulation of tumor necrosis factor secretion • interleukin-17 secretion • transcription initiation from RNA polymerase II promoter • inflammatory response • innate immune response • signal transduction • steroid hormone mediated signaling pathway • fatty acid homeostasis • positive regulation of insulin receptor signaling pathway • cellular response to lipopolysaccharide • negative regulation of interleukin-2 production • positive regulation of insulin secretion involved in cellular response to glucose stimulus • negative regulation of inflammatory response • glucose homeostasis • negative regulation of NF-kappaB transcription factor activity • positive regulation of adipose tissue development • cell-cell junction assembly • toll-like receptor 9 signaling pathway • negative regulation of monocyte chemotactic protein-1 production • positive regulation of glucose import in response to insulin stimulus • bile acid metabolic process • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of tumor necrosis factor-mediated signaling pathway • defense response to bacterium • negative regulation of interleukin-1 production • negative regulation of tumor necrosis factor production • negative regulation of interleukin-6 production • regulation of cholesterol homeostasis • triglyceride homeostasis • negative regulation of interferon-gamma production • regulation of transcription, DNA-templated • bile acid signaling pathway • positive regulation of transcription from RNA polymerase II promoter • positive regulation of phosphatidic acid biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9971	20186
Ensembl	ENSG00000012504	ENSMUSG00000047638
UniProt	Q96RI1	Q60641
RefSeq (mRNA)	NM_001206977 NM_001206978 NM_001206979 NM_001206992 NM_001206993 NM_005123	NM_001163504 NM_001163700 NM_009108
RefSeq (protein)	NP_001193906 NP_001193907 NP_001193908 NP_001193921 NP_001193922 NP_005114 NP_001193906.1 NP_001193908.1	NP_001157172.1 NP_001156976.1 NP_001156976 NP_001157172 NP_033134
Location (UCSC)	Chr 12: 100.47 – 100.56 Mb	Chr 10: 89.45 – 89.53 Mb
PubMed search

1OSH, 3BEJ, 3DCT, 3DCU, 3FLI, 3FXV, 3GD2, 3HC5, 3HC6, 3L1B, 3OKH, 3OKI, 3OLF, 3OMK, 3OMM, 3OOF, 3OOK, 3RUT, 3RUU, 3RVF, 3P88, 3P89, 4OIV, 4WVD, 4QE6, 4QE8

9971

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